Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2
F. Zech, D. Schniertshauer, C. Jung, A. Herrmann, Q. Xie, R. Nchioua, C. Prelli Bozzo, M. Volcic, L. Koepke, J. Krueger, S. Heller, A. Kleger, T. Jacob, K.-K. Conzelmann, A. Ensser, , F. Kirchhoff
The paper shows that a single amino acid mutation in the Spike protein of bat coronavirus RaTG13 enables it to use human ACE2 for infection.
bioRxiv · May 31, 2021 · PreprintMicrobiology