K.-K. Conzelmann

Functional synapses between small cell lung cancer and glutamatergic neurons

This study identifies glutamatergic synaptic interactions between SCLC cells and neurons, showing that these interactions support tumor growth and can be targeted therapeutically.

Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2

The paper shows that a single amino acid mutation in the Spike protein of bat coronavirus RaTG13 enables it to use human ACE2 for infection.

Imperfect innate immune antagonism renders SARS-CoV-2 vulnerable towards IFN-γ and -{lambda}

This study identifies SARS-CoV-2's vulnerability to IFN-γ and -λ due to its inefficient antagonism of type I and II IFN responses, suggesting potential therapeutic strategies.

Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19

This paper develops a safe and effective vaccine platform using rhabdovirus replicons that present the SARS-CoV-2 RBD as VLPs, inducing strong neutralizing antibodies in mice.

Mitochondria-ER contacts in reactive astrocytes coordinate local perivascular domains to promote vascular remodelling

This study shows that mitochondrial dynamics in astrocytes coordinate perivascular domains to promote vascular remodeling after injury.