S. Heller

Host factor PLAC8 is required for pancreas infection by SARS-CoV-2

This study shows that PLAC8 is required for SARS-CoV-2 infection of the pancreas and links pancreatic enzyme levels to COVID-19 severity.

Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ears

The paper presents a single-cell transcriptomic atlas of human inner ears, revealing increased regeneration in diseased utricles and new cell type markers.

Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2

The paper shows that a single amino acid mutation in the Spike protein of bat coronavirus RaTG13 enables it to use human ACE2 for infection.

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition

This study shows that IFITM proteins are required for SARS-CoV-2 infection and can be targeted to inhibit viral entry and replication.

Remdesivir but not famotidine inhibits SARS-CoV-2 replication in human pluripotent stem cell-derived intestinal organoids

This study uses human intestinal organoids to show that remdesivir inhibits SARS-CoV-2 replication, while famotidine does not.

Single-cell proteomics reveals downregulation of TMSB4X to drive actin release for stereocilia assembly

The paper uses single-cell proteomics to show TMSB4X downregulation drives actin release for stereocilia assembly in hair cells.