F. Zech

SARS-CoV-2 Omicron Envelope T9I adaptation confers resistance to autophagy

The paper shows that the T9I mutation in the SARS-CoV-2 E protein confers autophagy resistance in Omicron variants, contributing to their spread.

Attenuated replication and damaging effects of SARS-CoV-2 Omicron in an intestinal epithelial barrier model

This study compares the effects of SARS-CoV-2 early strains and Omicron variants on intestinal barrier function using a human gut epithelial model, finding Omicron causes less damage.

Determinants of Spike Infectivity, Processing and Neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

This study examines how specific mutations in the SARS-CoV-2 Omicron Spike protein affect infectivity, processing, and neutralization by antibodies.

SARS-CoV-2 variants of concern are dependent on IFITM2 for efficient replication in human lung cells

The paper was withdrawn due to duplicate submission and is not intended for citation.

SARS-CoV-2 variants of concern remain dependent on IFITM2 for efficient replication in human lung cells

This study shows that SARS-CoV-2 variants of concern (VOCs) require IFITM2 for efficient replication in human lung cells, with IFITM2 depletion reducing viral RNA and infectious virus production by over four orders of magnitude.

The Delta variant of SARS-CoV-2 maintains high sensitivity to interferons in human lung cells

This study examines IFN sensitivity of SARS-CoV-2 variants, finding Delta remains as sensitive as early isolates, while Alpha, Beta, and Gamma show increased resistance.

Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2

The paper shows that a single amino acid mutation in the Spike protein of bat coronavirus RaTG13 enables it to use human ACE2 for infection.

Imperfect innate immune antagonism renders SARS-CoV-2 vulnerable towards IFN-γ and -{lambda}

This study identifies SARS-CoV-2's vulnerability to IFN-γ and -λ due to its inefficient antagonism of type I and II IFN responses, suggesting potential therapeutic strategies.

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition

This study shows that IFITM proteins are required for SARS-CoV-2 infection and can be targeted to inhibit viral entry and replication.

Alpha-1 antitrypsin inhibits SARS-CoV-2 infection

The paper identifies 1-antitrypsin as a specific inhibitor of SARS-CoV-2, showing it blocks viral infection of human airway epithelium at physiological concentrations.