Reprogramming Alveolar Macrophage Responses to TGF-β Reveals CCR2+ Monocyte Activity that Promotes Bronchiolitis Obliterans Syndrome
Z. Liu, F. Liao, J. Zhu, D. Zhou, G. S. Heo, H. P. Luehmann, D. Scozzi, A. Parks, R. Hachem, D. Byers, L. K. Tague, H. S. Kulkarni, M. Cano, B. W. Wong, W. Li, , A. E. Gelman
This study identifies alveolar macrophage reprogramming by ECP that reduces TGF-β bioavailability and prevents BOS by inhibiting CCR2+ monocyte-driven inflammation.
bioRxiv · Jan 27, 2022 · PreprintImmunology