M. Ibrahim

RESPIRATION DEFECTS LIMIT SERINE SYNTHESIS REQUIRED FOR LUNG CANCER GROWTH AND SURVIVAL

This study shows that mitochondrial DNA mutations in NSCLC cause respiration defects, leading to glucose dependency, reduced serine synthesis, and increased cancer survival.

TRIP12 governs DNA Polymerase β involvement in DNA damage response and repair

This study identifies TRIP12 as a regulator of DNA polymerase β involvement in DNA damage response and repair by controlling its trafficking and chromatin loading.

Molecular Identification of Echinococcus spp. and other Taeniid Tapeworms Using Next Generation Sequence Analysis of PCR Amplified 18s rRNA gene

This study develops a PCR-NGS method to detect Echinococcus spp. DNA in dog fecal samples, identifying E. granulosus in 10% of samples with high specificity.

Why is the Omicron main protease of SARS-CoV-2 less stable than its wild-type counterpart? A crystallographic, biophysical, and theoretical study of the free enzyme and its complex with inhibitor 13b-K

This study investigates why the Omicron variant's main protease is less stable than the wild-type by analyzing its structure, enzymatic activity, and biophysical properties.

The rural urban divide, insights from immuno-genetic profiles and implications for health

The paper analyzes genotype and gene expression differences between rural and urban populations in eastern Sudan, finding higher cytokine expression and genetic variation in rural samples linked to health disparities.

Estrogen prevents age-dependent beige adipogenesis failure through NAMPT-controlled ER stress pathway

This study shows estrogen prevents age-related failure in beige adipogenesis by controlling ER stress via NAMPT, improving energy expenditure and glucose tolerance in mice.

Combining molecular dynamics simulations and X-ray scattering techniques for the accurate treatment of protonation degree and packing of ionizable lipids in monolayers

Adsorbing DNA to mica by cations: Influence of the valency and ion type

The paper investigates how different cations affect DNA adsorption to mica surfaces, finding that K+ and Mg2+/Ca2+ provide strong binding through specific ion-DNA or ion-surface contacts.

LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammation

This study identifies LRRK2 as a regulator of the unfolded protein response and antigen presentation in macrophages during inflammation, linking it to immune response mechanisms.

Structural Insights on Ionizable Dlin-MC3-DMA Lipids in DOPC Layers by Combining Accurate Atomistic Force Fields, Molecular Dynamics Simulations and Neutron Reflectivity

This study develops and validates force field parameters for MC3 lipids using molecular dynamics and neutron reflectivity experiments to better model lipid nanoparticle structures.

Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair

This study shows that cleavage of cFLIP by Caspase-8 limits cell death during viral infection and tissue injury, promoting tissue repair.

GPR183 targets lung-resident CD301b+ conventional dendritic cells type 2 to a subtissular TSLP-TSLP receptor-mediated survival niche within the adventitial cuff

This study identifies GPR183 as a key receptor guiding CD301b+ cDC2 to a TSLP-dependent survival niche in the lung adventitial cuff.

Remote adipose tissue-derived stromal cells of patients with lung adenocarcinoma generate a similar malignant microenvironment of the lung stromal counterpart

The paper shows that remote adipose-derived stromal cells from lung adenocarcinoma patients create a malignant microenvironment similar to local lung stromal cells, through shared secreted factors and miRNA expression.

Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer

This study quantifies the mutagenic activities of APOBEC3A and APOBEC3B in a human cell line and compares their mutation signatures to breast cancer genomes, showing both enzymes contribute to the mutation landscape.

Circulating Mitochondrial DNA is an Early Indicator of Severe Illness and Mortality from COVID-19

This study shows that high levels of circulating mitochondrial DNA predict severe illness and mortality in COVID-19 patients.

Sero-prevalence of brucellosis, Q-fever and Rift Valley Fever in humans and livestock in Somali region, Ethiopia

This study assesses seroprevalence of brucellosis, Q-fever, and Rift Valley Fever in humans and livestock in Ethiopia, finding high Q-fever and RVF rates in camels and notable human exposure.

Caldicellulosiruptor bescii regulates pilus expression in response to the polysaccharide, xylan

This study shows that Caldicellulosiruptor bescii uses type IV pili to attach to plant polysaccharides, with xylan inducing the highest pilin expression and direct interaction.

A qPCR assay for Bordetella pertussis cells that enumerates both live and dead bacteria.

The paper develops a qPCR assay to quantify both live and dead Bordetella pertussis bacteria in human challenge model samples.

Long-term metabolic consequences of acute dioxin exposure differ between male and female mice

This study examines the long-term metabolic effects of acute dioxin exposure in male and female mice, revealing sex-dependent differences in insulin levels and beta cell function.