K. Zhou

ARHGAP32 as a novel RhoGAP interacting with desmoplakin is required for desmosomal organization and assembly

This study identifies ARHGAP32 as a RhoGAP interacting with desmoplakin, essential for desmosomal organization and epithelial cell sheet integrity by regulating actomyosin contractility.

MICLEAR: Intelligent Molecular Cytology for Intraoperative Margin Assessment of Pancreatic Ductal Adenocarcinoma

MICLEAR uses Raman imaging and machine learning to assess PDAC surgical margins with high accuracy and speed.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

DNA Nanostructure-Guided Assembly of Proteins into Programmable Shapes

This paper describes a method using DNA origami to guide the assembly of protein-DNA conjugates into programmable nanostructures with controlled stoichiometry and geometry.

The effect of circulation rate on the water quality of container-type recirculation aquaculture system under different feeding rates of Schizothorax wangchiachii

This study examines how circulation rates affect water quality in a recirculation aquaculture system with varying feeding rates of Schizothorax wangchiachii, finding optimal circulation rates for different feed levels.

The TRIP6/LATS1 complex constitutes the tension sensor of α-catenin/vinculin at both bicellular and tricellular junctions

This study identifies TRIP6 and LATS1 as novel components of the tension sensor complex at bicellular and tricellular junctions, revealing their distinct distribution and dynamics compared to α-catenin/vinculin.

Engineering Escherichia coli to produce aromatic chemicals from ethylene glycol

This study engineers Escherichia coli to produce aromatic chemicals from ethylene glycol, achieving higher yields than glucose and demonstrating feasibility with waste PET-derived EG.

Accurate and Rapid Detection of Peritoneal Metastasis from Gastric Cancer by AI-assisted Stimulated Raman Cytology

This paper develops an AI-assisted stimulated Raman cytology method to detect peritoneal metastasis in gastric cancer with high accuracy and speed.

MC1R reduces scarring and rescues stalled healing in a preclinical chronic wound model

This study shows that MC1R agonist reduces scarring and improves healing in a chronic wound model by enhancing angiogenesis, lymphangiogenesis, and reducing inflammation.

Improving glycine utilization in Escherichia coli

This study engineers Escherichia coli to utilize glycine as a carbon and nitrogen source, identifying a stable pathway and genetic modifications that enhance its metabolic efficiency.

Improved Genome Editing by an Engineered CRISPR-Cas12a

This paper improves CRISPR-Cas12a genome editing by combining rational engineering and directed evolution to enhance homology-directed repair efficiency.

Development and application of an uncapped mRNA platform

The paper develops an uncapped mRNA platform and demonstrates its effectiveness in inducing immune responses and protein expression in vitro and in vivo.

Atomic model of Vesicular Stomatitis Virus and Mechanism of Assembly

The paper determines the in situ atomic structures of VSV components using cryoEM and sub-particle reconstruction, revealing their assembly mechanism through interactions.

Cryo-EM structure of amyloid fibril formed by α-synuclein familial A53E mutation

The paper presents a cryo-EM structure of α-synuclein fibrils with the A53E mutation, showing structural differences that may affect aggregation kinetics and disease progression.

Tracking influenza a virus infection in the lung from hematological data with machine learning

This study uses machine learning to predict lung viral load and immune markers from hematological data in a murine influenza infection model.

Multi-parameter optical imaging of immune cell activity in chimeric antigen receptor T-cell and checkpoint blockade therapies

The paper develops a small molecule for imaging immune cell activity in cancer immunotherapies and demonstrates its utility in predicting treatment outcomes.

Global dissemination of tet(X3) and tet(X6) among livestock-associated Acinetobacter is sporadically mediated by highly diverse plasmidomes

This study identifies sporadic dissemination of tet(X3) and tet(X6) in livestock-associated Acinetobacter through diverse plasmidomes, highlighting the need for One Health surveillance.

Perinatal maternal chronic exposure to dibutyl phthalate promotes visceral obesity in adult female offspring

This study shows that maternal exposure to dibutyl phthalate during pregnancy and lactation leads to increased visceral obesity in adult female offspring without affecting serum glucolipid levels or the PI3K/AKT pathway in muscle.

Torsions-Driven Root Helical Growth, Waving And Skewing In Arabidopsis

This study investigates the torsions-driven mechanism of helical root growth, waving, and skewing in Arabidopsis, emphasizing the role of cortical microtubules and cellulose microfibrils.

Structure and function of the chromatin remodeler SMARCAD1 with its nucleosome substrate

This study reveals the structure and mechanism of SMARCAD1, showing it transfers histone octamers between DNA segments and can assemble de novo nucleosomes.

PRSS2 stimulates tumor growth by remodeling the TME via repression of Tsp1

This study identifies PRSS2 as a factor that represses Tsp-1 in the tumor microenvironment by binding to LRP1, promoting tumor growth.

High-throughput Single-cell CNV Detection Reveals Clonal Evolution During Hepatocellular Carcinoma Recurrence

This study develops a high-throughput single-cell DNA library preparation method for CNV detection and applies it to identify clonal evolution in hepatocellular carcinoma recurrence.

Chemoproteomics Maps Glycolytic Targetome in Cancer Cells

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

Characterization of a clinical Enterobacter hormaechei strain belonging to epidemic clone ST418 co-carrying blaNDM-1, blaIMP-4 and mcr-9.1

The paper characterizes a clinical Enterobacter hormaechei strain co-carrying blaNDM-1, blaIMP-4, and mcr-9.1, highlighting the convergence of resistance genes in an epidemic clone.

Dynamic Laser Speckle Imaging meets Machine Learning to enable Rapid Antibacterial Susceptibility Testing (DyRAST)

DyRAST uses dynamic laser speckle imaging and machine learning to rapidly predict antibiotic minimum inhibitory concentrations in E. coli within 60 minutes.

Aspiration-assisted Freeform Bioprinting of Tissue Spheroids in a Yield-stress Gel

This study introduces a new bioprinting method using a yield-stress granular gel to position and assemble tissue spheroids in 3D for cartilage and bone tissue construction.

Constructing an ethanol utilization pathway in Escherichia coli to produce acetyl-CoA derived compounds

This paper engineers Escherichia coli to convert ethanol into acetyl-CoA and its derivatives through a heterologous pathway, achieving efficient ethanol consumption and production of PHB and prenol.

Sorting liposomes of distinct sizes by DNA-brick assisted centrifugation

This paper introduces a DNA-brick assisted centrifugation method to sort liposomes by size, enabling the study of membrane curvature effects on protein activity.

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

This study determines the cryoEM structure of α-synuclein fibrils with the E46K mutation, revealing a more stable and pathogenic fibril structure compared to wild-type.

HIV-1 Envelope and MPER antibody structures in lipid assemblies

This study presents methods to incorporate full-length HIV-1 Env into lipid assemblies for structural analysis, revealing the quaternary epitope of an MPER antibody and Env tilting during neutralization.