Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
E. Lyapina, E. Marin, A. Gusach, P. Orekhov, A. Gerasimov, A. Luginina, D. Vakhrameev, M. Ergasheva, M. Kovaleva, G. Khusainov, P. Khorn, M. Shevtsov, K. Kovalev, I. Okhrimenko, P. Popov, , V. Cherezov
The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.
bioRxiv · Feb 25, 2022Biophysics