Author

M. Shevtsov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 2 Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:structural biology· 2

Frequent Co-Authors

A. Mishin· 4 shared A. Luginina· 3 shared E. Marin· 3 shared K. Kovalev· 3 shared V. Borshchevskiy· 3 shared V. Gordeliy· 3 shared A. Gilep· 2 shared A. Gusach· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiophysics

A. Mishin

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Functional GPCR expression in eukaryotic LEXSY system

A. Luginina, I. Maslov, P. Khorn, O. Volkov, A. Khnykin, P. Kuzmichev, M. Shevtsov, A. Belousov, D. Dashevskii, D. Kornilov, E. Bestsennaia, J. Hofkens, J. Hendrix, T. Gensch, V. Cherezov, , V. I. Borshchevskiy

The paper compares GPCR expression in the LEXSY eukaryotic system to insect cells, finding higher protein yield in LEXSY for the A2A adenosine receptor.

Journal of Molecular Biology · Dec 1, 2023Peer-reviewedBiophysics

Host inducible-HSP70A1A is an irresistible drug target to combat SARS-CoV-2 infection and pathogenesis

P. Joshi, S. Garg, S. Mani, K. Jakhar, M. Marothia, R. Shoaib, S. Biswas, J. Singhal, A. Behl, A. K. Kahlon, M. Shevtsov, P. Garg, S. Singh, A. Ranganathan

This study shows that inhibiting host Hsp70 reduces SARS-CoV-2 infection more effectively than Remdesivir by blocking viral entry and autophagy.

bioRxiv · May 5, 2023 · PreprintMicrobiology

Structural insights into 3Fe-4S ferredoxins diversity in M.tuberculosis highlighted by a first redox complex with P450.

A. Gilep, T. Varaksa, S. Bukhdruker, A. Kavaleuski, Y. Ryzhykau, S. Smolskaya, T. Sushko, K. Tsumoto, I. Grabovec, I. Kapranov, I. Okhrimenko, E. Marin, M. Shevtsov, A. Mishin, K. Kovalev, , N. Strushkevich

The paper solves the structures of 3Fe-4S ferredoxins from M. tuberculosis and their complex with CYP143, revealing structural and functional insights into redox interactions.

bioRxiv · Nov 2, 2022 · PreprintBiochemistry

Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

E. Lyapina, E. Marin, A. Gusach, P. Orekhov, A. Gerasimov, A. Luginina, D. Vakhrameev, M. Ergasheva, M. Kovaleva, G. Khusainov, P. Khorn, M. Shevtsov, K. Kovalev, I. Okhrimenko, P. Popov, , V. Cherezov

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

bioRxiv · Feb 25, 2022Biophysics

Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane

L. Zhao, F. Chen, O. Quitt, M. Festag, M. Ringelhan, K. Wisskirchen, J. Hasreiter, L. Yakovleva, C. Sureau, F. Bohne, M. Aichler, V. Bruss, M. Shevtsov, M. A. van de Klundert, F. Momburg, , U. Protzer

This study shows HBV envelope proteins are present on the host cell plasma membrane and can be targeted by T-cells for therapeutic purposes.

bioRxiv · Dec 21, 2020Microbiology

Metabolic fate of human immunoactive sterols in Mycobacterium tuberculosis

T. Varaksa, S. Bukhdruker, I. Grabovec, E. Marin, A. Kavaleuski, A. Gusach, K. Kovalev, I. Maslov, A. Luginina, D. Zabelskiy, R. Astashkin, M. Shevtsov, S. Smolskaya, A. Kavaleuskaya, P. Shabunya, , N. Strushkevich

The paper identifies Mtb enzymes that metabolize human immune oxysterols and vitamin D3 derivatives, revealing a potential drug target for tuberculosis treatment.

bioRxiv · Jul 7, 2020Biochemistry