Author

P. Khorn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

V. Cherezov· 4 shared A. Luginina· 3 shared A. Mishin· 3 shared I. Maslov· 3 shared J. Hendrix· 3 shared J. Hofkens· 3 shared P. Kuzmichev· 3 shared P. Orekhov· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiophysics

V. Cherezov

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Functional GPCR expression in eukaryotic LEXSY system

A. Luginina, I. Maslov, P. Khorn, O. Volkov, A. Khnykin, P. Kuzmichev, M. Shevtsov, A. Belousov, D. Dashevskii, D. Kornilov, E. Bestsennaia, J. Hofkens, J. Hendrix, T. Gensch, V. Cherezov, , V. I. Borshchevskiy

The paper compares GPCR expression in the LEXSY eukaryotic system to insect cells, finding higher protein yield in LEXSY for the A2A adenosine receptor.

Journal of Molecular Biology · Dec 1, 2023Peer-reviewedBiophysics

Monitoring GPCR Conformation with GFP-Inspired Dyes

A. Belousov, I. Maslov, P. Orekhov, P. Khorn, P. Kuzmichev, N. Baleeva, V. Motov, A. Bogorodskiy, S. Krasnova, K. Mineev, D. Zinchenko, E. Zernii, V. Ivanovich, S. Permyakov, J. Hofkens, , V. Borshchevskiy

This study develops GFP-inspired dyes to monitor ligand-induced conformational changes in GPCRs, showing fluorescence responses to agonists and allosteric modulators.

bioRxiv · Jun 1, 2023Biophysics

Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

E. Lyapina, E. Marin, A. Gusach, P. Orekhov, A. Gerasimov, A. Luginina, D. Vakhrameev, M. Ergasheva, M. Kovaleva, G. Khusainov, P. Khorn, M. Shevtsov, K. Kovalev, I. Okhrimenko, P. Popov, , V. Cherezov

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

bioRxiv · Feb 25, 2022Biophysics

Sub-millisecond conformational dynamics of the A2A adenosine receptor revealed by single-molecule FRET

I. Maslov, O. Volkov, P. Khorn, P. Orekhov, A. Gusach, P. Kuzmichev, A. Gerasimov, A. Luginina, Q. Coucke, A. Bogorodskiy, V. Gordeliy, S. Wanninger, A. Barth, J. Hofkens, V. Cherezov, , V. Borshchevskiy

This study uses smFRET to analyze the conformational dynamics of the A2A adenosine receptor, revealing slow and fast dynamics in different ligand-bound states.

bioRxiv · Nov 26, 2020Biophysics