Author

P. Orekhov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:fluorescence / live-cell microscopy· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

V. Borshchevskiy· 4 shared V. Gordeliy· 4 shared I. Gushchin· 3 shared P. Khorn· 3 shared V. Cherezov· 3 shared A. Bogorodskiy· 2 shared A. Gerasimov· 2 shared A. Gusach· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersBiophysics

V. Borshchevskiy

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Author profile →

5 papers

Recent·Most cited

Monitoring GPCR Conformation with GFP-Inspired Dyes

A. Belousov, I. Maslov, P. Orekhov, P. Khorn, P. Kuzmichev, N. Baleeva, V. Motov, A. Bogorodskiy, S. Krasnova, K. Mineev, D. Zinchenko, E. Zernii, V. Ivanovich, S. Permyakov, J. Hofkens, , V. Borshchevskiy

This study develops GFP-inspired dyes to monitor ligand-induced conformational changes in GPCRs, showing fluorescence responses to agonists and allosteric modulators.

bioRxiv · Jun 1, 2023Biophysics

Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

E. Lyapina, E. Marin, A. Gusach, P. Orekhov, A. Gerasimov, A. Luginina, D. Vakhrameev, M. Ergasheva, M. Kovaleva, G. Khusainov, P. Khorn, M. Shevtsov, K. Kovalev, I. Okhrimenko, P. Popov, , V. Cherezov

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

bioRxiv · Feb 25, 2022Biophysics

Structure and dynamics of the SARS-CoV-2 envelope protein monomer

A. Kuzmin, P. Orekhov, R. Astashkin, V. Gordeliy, I. Gushchin

This study uses molecular dynamics simulations to analyze the structure and dynamics of the SARS-CoV-2 envelope protein monomer, revealing its membrane orientation and interactions with host factors.

bioRxiv · Mar 10, 2021Biophysics

Sub-millisecond conformational dynamics of the A2A adenosine receptor revealed by single-molecule FRET

I. Maslov, O. Volkov, P. Khorn, P. Orekhov, A. Gusach, P. Kuzmichev, A. Gerasimov, A. Luginina, Q. Coucke, A. Bogorodskiy, V. Gordeliy, S. Wanninger, A. Barth, J. Hofkens, V. Cherezov, , V. Borshchevskiy

This study uses smFRET to analyze the conformational dynamics of the A2A adenosine receptor, revealing slow and fast dynamics in different ligand-bound states.

bioRxiv · Nov 26, 2020Biophysics

Molecular mechanism of light-driven sodium pumping

K. Kovalev, R. Astashkin, I. Gushchin, P. Orekhov, D. Volkov, E. Zinovev, E. Marin, M. Rulev, A. Alekseev, A. Royant, P. Carpentier, S. Vaganova, C. Baeken, I. Sergeev, D. Zabelskii, , V. Gordeliy

The paper elucidates the molecular mechanism of Na+ pumping by KR2 rhodopsin using crystal structures and molecular dynamics, revealing a switching mechanism and structural similarities to channelrhodopsins.

bioRxiv · Jan 29, 2020Biophysics