Author

A. Gusach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

V. Borshchevskiy· 4 shared A. Luginina· 3 shared E. Marin· 3 shared V. Gordeliy· 3 shared A. Gerasimov· 2 shared A. Gilep· 2 shared A. Kavaleuski· 2 shared A. Mishin· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersBiophysics

V. Borshchevskiy

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4 papers

Recent·Most cited

Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

E. Lyapina, E. Marin, A. Gusach, P. Orekhov, A. Gerasimov, A. Luginina, D. Vakhrameev, M. Ergasheva, M. Kovaleva, G. Khusainov, P. Khorn, M. Shevtsov, K. Kovalev, I. Okhrimenko, P. Popov, , V. Cherezov

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

bioRxiv · Feb 25, 2022Biophysics

Sub-millisecond conformational dynamics of the A2A adenosine receptor revealed by single-molecule FRET

I. Maslov, O. Volkov, P. Khorn, P. Orekhov, A. Gusach, P. Kuzmichev, A. Gerasimov, A. Luginina, Q. Coucke, A. Bogorodskiy, V. Gordeliy, S. Wanninger, A. Barth, J. Hofkens, V. Cherezov, , V. Borshchevskiy

This study uses smFRET to analyze the conformational dynamics of the A2A adenosine receptor, revealing slow and fast dynamics in different ligand-bound states.

bioRxiv · Nov 26, 2020Biophysics

Hydroxylation of antitubercular drug candidate, SQ109, by mycobacterial cytochrome P450

S. Bukhdruker, T. Varaksa, I. Grabovec, E. Marin, P. Shabunya, M. Kadukova, S. Grudinin, A. Kavaleuski, A. Gusach, A. Gilep, V. Borshchevskiy, N. Strushkevich

The paper shows that Mycobacterium tuberculosis CYP124 hydroxylates SQ109, a drug candidate, and potentially affects its interaction with MmpL3.

bioRxiv · Aug 27, 2020Biochemistry

Metabolic fate of human immunoactive sterols in Mycobacterium tuberculosis

T. Varaksa, S. Bukhdruker, I. Grabovec, E. Marin, A. Kavaleuski, A. Gusach, K. Kovalev, I. Maslov, A. Luginina, D. Zabelskiy, R. Astashkin, M. Shevtsov, S. Smolskaya, A. Kavaleuskaya, P. Shabunya, , N. Strushkevich

The paper identifies Mtb enzymes that metabolize human immune oxysterols and vitamin D3 derivatives, revealing a potential drug target for tuberculosis treatment.

bioRxiv · Jul 7, 2020Biochemistry