Author

V. Cherezov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:protein structure prediction· 3 Assay:fluorescence / live-cell microscopy· 2 Assay:protein structure· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

P. Khorn· 4 shared A. Luginina· 3 shared A. Mishin· 3 shared I. Maslov· 3 shared J. Hendrix· 3 shared J. Hofkens· 3 shared P. Kuzmichev· 3 shared P. Orekhov· 3 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiophysics

P. Khorn

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Functional GPCR expression in eukaryotic LEXSY system

A. Luginina, I. Maslov, P. Khorn, O. Volkov, A. Khnykin, P. Kuzmichev, M. Shevtsov, A. Belousov, D. Dashevskii, D. Kornilov, E. Bestsennaia, J. Hofkens, J. Hendrix, T. Gensch, V. Cherezov, , V. I. Borshchevskiy

The paper compares GPCR expression in the LEXSY eukaryotic system to insect cells, finding higher protein yield in LEXSY for the A2A adenosine receptor.

Journal of Molecular Biology · Dec 1, 2023Peer-reviewedBiophysics

MicroED structure of the human vasopressin 1B receptor

A. Shiriaeva, M. W. Martynowycz, W. J. Nicolas, V. Cherezov, T. Gonen

This paper determines the structure of the human vasopressin 1B receptor using MicroED, overcoming challenges in GPCR structural determination.

bioRxiv · Jul 5, 2023 · PreprintBiochemistry

Monitoring GPCR Conformation with GFP-Inspired Dyes

A. Belousov, I. Maslov, P. Orekhov, P. Khorn, P. Kuzmichev, N. Baleeva, V. Motov, A. Bogorodskiy, S. Krasnova, K. Mineev, D. Zinchenko, E. Zernii, V. Ivanovich, S. Permyakov, J. Hofkens, , V. Borshchevskiy

This study develops GFP-inspired dyes to monitor ligand-induced conformational changes in GPCRs, showing fluorescence responses to agonists and allosteric modulators.

bioRxiv · Jun 1, 2023Biophysics

Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

E. Lyapina, E. Marin, A. Gusach, P. Orekhov, A. Gerasimov, A. Luginina, D. Vakhrameev, M. Ergasheva, M. Kovaleva, G. Khusainov, P. Khorn, M. Shevtsov, K. Kovalev, I. Okhrimenko, P. Popov, , V. Cherezov

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

bioRxiv · Feb 25, 2022Biophysics

iDEP-assisted isolation of insulin secretory vesicles

M. Barekatain, Y. Liu, Z. Wang, V. Cherezov, S. Fraser, K. L. White, M. A. Hayes

The paper uses DC-iDEP to isolate insulin vesicles from pancreatic β-cells and identifies distinct distribution patterns in response to glucose stimulation.

bioRxiv · Dec 1, 2021 · PreprintBiophysics

Sub-millisecond conformational dynamics of the A2A adenosine receptor revealed by single-molecule FRET

I. Maslov, O. Volkov, P. Khorn, P. Orekhov, A. Gusach, P. Kuzmichev, A. Gerasimov, A. Luginina, Q. Coucke, A. Bogorodskiy, V. Gordeliy, S. Wanninger, A. Barth, J. Hofkens, V. Cherezov, , V. Borshchevskiy

This study uses smFRET to analyze the conformational dynamics of the A2A adenosine receptor, revealing slow and fast dynamics in different ligand-bound states.

bioRxiv · Nov 26, 2020Biophysics

MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP

M. W. Martynowycz, A. Shiriaeva, X. Ge, J. Hattne, B. L. Nannenga, V. Cherezov, T. Gonen

The paper determines the structure of the human A2A adenosine receptor using MicroED after converting LCP to sponge phase and cryoFIB milling, achieving 2.8 Å resolution.

bioRxiv · Sep 27, 2020Biophysics