An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion
I. Noordstra, M. Diez Hermoso, L. Schimmel, A. Bonfim-Melo, D. Currin-Ross, C. N. Duong, J. M. Kalappurakkal, R. G. Morris, D. Vestweber, S. Mayor, E. Gordon, P. Roca-Cusachs, A. S. Yap
The paper explains how E-cadherin-actin interactions mediate mechanical signals from cortical flows to inhibit epithelial cell migration based on contact orientation.
bioRxiv · Jul 28, 2021Cell Biology