Author

L. Schimmel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

I. Noordstra· 3 shared A. S. Yap· 2 shared E. Gordon· 2 shared J. D. van Buul· 2 shared P. Essebier· 2 shared T. Yordanov· 2 shared A. Bonfim-Melo· 1 shared A. C. I. van Steen· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

I. Noordstra

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

c-Src induced vascular malformations require localised matrix degradation at focal adhesions

P. Essebier, L. Schimmel, T. Yordanov, M. Keyser, A. Yu, I. Noordstra, B. Hill, A. S. Yap, S. J. Stehbens, A. Lagendijk, E. Gordon

This study shows that c-Src activation in endothelial cells causes vascular expansion through focal adhesion signaling and localized matrix degradation, which can be inhibited to prevent abnormal vascular growth.

bioRxiv · Sep 15, 2023Cell Biology

Comparative metabolomics and microbiome analysis of Ethanol vs. OMNImet/gene GUT fecal stabilization

H. Isokaanta, L. Pinto da Silva, N. Karu, T. Kallonen, A. K. Aatsinki, T. Hankemeier, L. Schimmel, E. Diaz, T. Hyotylainen, P. C. Dorrestein, R. Knight, M. Oresic, R. K. Daouk, A. M. Dickens, S. Lamichhane

This study compares the stability of fecal metabolome and microbiome using 95% ethanol and commercial kits under different storage conditions, finding comparable results to flash freezing.

bioRxiv · Aug 29, 2023 · PreprintBiochemistry

An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion

I. Noordstra, M. Diez Hermoso, L. Schimmel, A. Bonfim-Melo, D. Currin-Ross, C. N. Duong, J. M. Kalappurakkal, R. G. Morris, D. Vestweber, S. Mayor, E. Gordon, P. Roca-Cusachs, A. S. Yap

The paper explains how E-cadherin-actin interactions mediate mechanical signals from cortical flows to inhibit epithelial cell migration based on contact orientation.

bioRxiv · Jul 28, 2021Cell Biology

Endothelial cells elicit a pro-inflammatory response to SARS-COV-2 without productive viral infection

L. Schimmel, K. Y. Chew, C. Stocks, T. Yordanov, P. Essebier, A. Kulasinghe, J. Monkman, A. F. R. d. S. Miggiolaro, C. Cooper, L. De Noronha, A. K. Lagendijk, K. Schroder, L. Labzin, E. J. Gordon, K. R. Short

This study shows that endothelial cells can be infected by SARS-CoV-2 but do not produce infectious virus, instead triggering an inflammatory response through sensing adjacent infections.

bioRxiv · Feb 14, 2021 · PreprintCell Biology

Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

J. J. G. Arts, E. K. Mahlandt, M. Grönloh, L. Schimmel, I. Noordstra, A. C. I. van Steen, S. Tol, J. van Rijssel, M. A. Nolte, M. Postma, S. Khuon, J. M. Heddleston, E. Wait, T. L. Chew, M. Winter, , J. D. van Buul

The paper identifies endothelial junctional membrane protrusions as preferred sites for neutrophil transmigration during inflammation and shows they depend on Rac1 activity.

bioRxiv · Jan 18, 2021Cell Biology

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis

M. van der Stoel, L. Schimmel, K. Nawaz, A.-M. van Stalborch, A. de Haan, A. Klaus-Bergmann, E. T. Valent, D. S. Koenis, G. P. van Nieuw Amerongen, C. J. de Vries, V. de Waard, M. Gloerich, J. D. van Buul, S. Huveneers

This study identifies DLC1 as a direct target of YAP/TAZ that regulates endothelial dynamics and sprouting angiogenesis.

bioRxiv · Sep 2, 2019Cell Biology