Cell BiologybioRxiv
Autophagy preferentially degrades non-fibrillar polyQ aggregates
D. Y. Zhao, F. J. Bauerlein, I. Saha…·F. Wilfling
This study shows autophagosomes preferentially degrade non-fibrillar polyQ aggregates by interacting with p62, while amyloid fibrils evade clearance due to their non-deformable structure.
DOI 10.1016/j.molcel.2024.04.018