Author

D.-F. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. C. Roman· 1 shared A. M. Gomes· 1 shared C. Kutter· 1 shared C. Schaniel· 1 shared D. Melguizo-Sanchis· 1 shared D. Prasad Bhattarai· 1 shared D. Zhu· 1 shared E. G. Demicco· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCell Biology

A. C. Roman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis of the human transcriptional Mediator complex modulated by its dissociable Kinase module

S.-F. Chen, T.-C. Chao, H. J. Kim, H.-C. Tang, S. Khadka, T. Li, D.-F. Lee, K. Murakami, T. G. Boyer, K.-L. Tsai

This study presents cryo-EM structures of the human Mediator complex and its CKM module, revealing how the CKM inhibits transcription by blocking Pol II and PIC assembly.

bioRxiv · Jul 1, 2024 · PreprintBiochemistry

ZFP207 controls pluripotency by multiple post-transcriptional mechanisms

S. Malla, D. Prasad Bhattarai, D. Melguizo-Sanchis, I. Atanasoai, P. Groza, A. C. Roman, D. Zhu, D.-F. Lee, C. Kutter, F. Aguilo

This study identifies ZFP207's role in maintaining mouse embryonic stem cell identity through post-transcriptional mechanisms, including alternative splicing and RNA-binding protein activity.

bioRxiv · Mar 2, 2021 · PreprintCell Biology

Oncogenic role of sFRP2 in P53-mutant osteosarcoma development via autocrine and paracrine mechanism

H. S. Kim, S. Yoo, J. M. Bernitz, Y. Yuan, A. M. Gomes, M. G. Daniel, J. Su, E. G. Demicco, J. Zhu, K. A. Moore, D.-F. Lee, I. R. Lemischka, C. Schaniel

This study identifies sFRP2 as an oncogenic driver in P53-mutant osteosarcoma through autocrine and paracrine mechanisms, showing its role in promoting tumor growth and poor survival.

bioRxiv · Jan 10, 2018Cancer Biology