E. R. Mardis

The paper identifies changes in the bone marrow microenvironment during preleukemic stages of AML, including an expanded CD55+ fibroblast population that supports preleukemic stem cells over normal HSCs.

This study shows that genetically modified myeloid cells releasing IL-2 can reprogram the glioma tumor microenvironment to enhance anti-tumor immunity in a mouse model.

The paper develops a 15-gene immune signature to identify T-cell infiltration in high-risk paediatric cancers, finding up to 31% of such cancers have infiltrating T-cells.

This study identifies genomic and transcriptomic alterations in non-cirrhotic hepatocellular carcinoma, revealing recurrent mutations and structural variants that may contribute to tumorigenesis.

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

This study tracks the molecular evolution of a pediatric ependymoma through multiple treatments, revealing how therapy shapes tumor subclonal diversity and neo-antigen landscapes.