R. Kulkarni

Cellular taxonomy of the preleukemic bone marrow niche of acute myeloid leukemia

The paper identifies changes in the bone marrow microenvironment during preleukemic stages of AML, including an expanded CD55+ fibroblast population that supports preleukemic stem cells over normal HSCs.

NLRP3 inflammasome is dispensable in methicillin resistant Staphylococcus aureus urinary tract infection

This study shows that NLRP3 inflammasome is not required for immune defenses against MRSA urinary tract infection in mice.

Defining the roles of pyruvate oxidation, TCA cycle, and mannitol metabolism in methicillin resistance Staphylococcus aureus urinary tract infection

This paper identifies metabolic pathways critical for MRSA survival in urinary tract infections and suggests potential therapeutic targets.

Genome-wide investigation of Cytochrome P450 superfamily of Aquilaria agallocha: association with terpenoids and phenylpropanoids biosynthesis

This study identifies and characterizes CYPs in Aquilaria agallocha, linking them to terpenoids and phenylpropanoids biosynthesis and validating their expression in stress-induced tissues.

Ending transmission of SARS-CoV-2: sterilizing immunity using an intranasal subunit vaccine

This paper develops an intranasal multi-antigen vaccine that prevents SARS-CoV-2 infection and transmission by targeting both spike and nucleocapsid proteins.

An intranasal nanoparticle STING agonist has broad protective immunity against respiratory viruses and variants

This study develops NanoSTING, an intranasal nanoparticle STING agonist, showing broad protection against respiratory viruses and variants in animal models.

FAM21 is critical for TLR2-CLEC4E-mediated dendritic cell function against Candida albicans

This study shows FAM21 is essential for dendritic cell function against Candida albicans by regulating TLR2/CLEC4E signaling and phagocytosis.

Glycosuria alters uropathogenic Escherichia coli global gene expression and virulence

This study shows glycosuria increases UPEC biofilm formation and alters gene expression, potentially contributing to UTI pathogenesis in diabetes.

Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters

This study evaluates two vaccinia virus-based SARS-CoV-2 vaccines in mice and hamsters, showing they induce neutralizing antibodies and protect against infection.

Human urine alters methicillin-resistant Staphylococcus aureus virulence and transcriptome

This study shows human urine alters MRSA virulence and transcriptome, affecting metabolic pathways, adherence, and surface properties.

Bidirectional interconversion between mutually exclusive tumorigenic and drug-tolerant melanoma cell phenotypes

This study identifies bidirectional interconversion between tumorigenic and drug-tolerant melanoma cell states through BRN2 expression, revealing distinct molecular programs and therapeutic implications.

Unique roles of ATAC and SAGA KAT2A complexes in normal and malignant hematopoiesis

The paper investigates the distinct roles of ATAC and SAGA KAT2A complexes in normal and malignant hematopoiesis, showing ATAC's essential role in stem/progenitor cell maintenance and SAGA's role in cell identity.

The effects of e-cigarette vapor exposure on the transcriptome and virulence of Streptococcus pneumoniae

This study examines how e-cigarette vapor affects the transcriptome and virulence of Streptococcus pneumoniae, finding nicotine-dependent transcriptome changes without affecting virulence.

Loss Of Kat2a Enhances Transcriptional Noise And Depletes Acute Myeloid Leukemia Stem-Like Cells

This study shows that loss of Kat2a increases transcriptional noise and reduces leukemia stem-like cells in AML by disrupting transcriptional homogeneity.