Author

E. A. Scheef

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:rat· 4 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Kaur· 4 shared D. Malouli· 3 shared D. N. Streblow· 3 shared H. Taher· 3 shared L. M. Sprehe· 3 shared S. G. Hansen· 3 shared C. Chan· 2 shared C. E. Otero· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

A. Kaur

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity

C. E. Otero, S. Petkova, M. Ebermann, H. Taher, N. John, K. Hoffmann, A. Davalos, M. J. Mostrom, R. M. Gilbride, C. Papen, A. Barber-Axthelm, E. A. Scheef, R. Barfield, L. M. Sprehe, S. Kendall, , P. Kolb

This study identifies and characterizes Rhesus CMV-encoded Fcγ-binding glycoproteins, showing they delay antibody-mediated immune control during primary infection.

bioRxiv · Feb 27, 2024Microbiology

The pentameric complex is not required for vertical transmission of cytomegalovirus in seronegative pregnant rhesus macaques

H.-Y. Wang, H. Taher, C. N. Kreklywich, K. A. Schmidt, E. A. Scheef, R. Barfield, C. E. Otero, S. Valencia, C. M. Crooks, A. Mirza, K. Woods, N. V. Burgt, T. F. Kowalik, P. A. Barry, S. G. Hansen, , D. Malouli

The study shows that deleting the pentameric complex in rhesus CMV does not affect congenital transmission in seronegative pregnant rhesus macaques.

bioRxiv · Jun 15, 2023 · PreprintMicrobiology

Adjuvant and immunomodulatory potential of Natural Killer T (NKT) activation by NKTT320

N. G. Bond, M. D. Fahlberg, S. Yu, N. Rout, D. Tran, T. Fitzpatrick-Schmidt, L. M. Sprehe, E. A. Scheef, J. C. Mudd, R. G. Schaub, A. Kaur

This study evaluates the adjuvant and immunomodulatory effects of NKTT320, a humanized monoclonal antibody that activates iNKT cells, showing enhanced immune responses and inflammation resolution.

bioRxiv · Apr 27, 2021 · PreprintImmunology

In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome

H. Taher, E. Mahyari, C. Kreklywich, L. S. Uebelhoer, M. R. McArdle, M. J. Moström, A. Bhusari, M. Nekorchuk, T. Whitmer, E. A. Scheef, L. M. Sprehe, D. Roberts, C. M. Hughes, K. A. Jackson, A. N. Selseth, , D. Malouli

This paper constructs a full-length rhesus cytomegalovirus (RhCMV) by repairing mutations in the 68-1 strain and shows it replicates more effectively in vivo compared to the passaged strain.

bioRxiv · Jun 2, 2020Microbiology

CD8+ lymphocytes modulate Zika virus dynamics and tissue dissemination and orchestrate antiviral immunity

B. Schouest, M. Fahlberg, E. A. Scheef, M. J. Ward, K. Headrick, D. M. Szeltner, R. V. Blair, M. H. Gilbert, L. A. Doyle-Meyers, V. W. Danner, M. C. Bonaldo, D. M. Wesson, A. T. Panganiban, N. J. Maness

This study shows CD8+ lymphocytes control ZIKV dissemination and immune regulation in nonhuman primates by affecting viremia, tissue viral loads, and immune responses.

bioRxiv · Jul 11, 2019 · PreprintImmunology