D. Roberts

Leveraging the genetic diversity of trout in the rivers of the British Isles and northern France to understand the movements of sea trout (Salmo trutta L.) around the English Channel

This study uses genetic markers to track movements of sea trout in the English Channel and southern North Sea, revealing both local and long-distance migration patterns.

ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways

This paper identifies how HCMV targets ADAM17 to modulate surface proteins and immune pathways, revealing a novel viral immunomodulation strategy.

Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages

This study identifies fibroblastic reticular cells (FRCs) as essential for supporting lymph node-resident macrophages through CSF1 and CSF1R signaling.

Maturation of Human Long-lived Plasma Cells Results in Resistance to Apoptosis by Transcriptional and Epigenetic Regulation

This study shows human blood ASCs undergo transcriptional and epigenetic changes in the BM microniche to become apoptotic-resistant LLPC.

In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome

This paper constructs a full-length rhesus cytomegalovirus (RhCMV) by repairing mutations in the 68-1 strain and shows it replicates more effectively in vivo compared to the passaged strain.

A Homogeneous SIRPα-CD47 Cell-Based, Ligand-Binding Assay: Utility for Small Molecule Drug Development in Immuno-oncology.

This paper develops a cell-based ligand-binding assay to identify small molecule inhibitors of the SIRP-CD47 interaction for immuno-oncology drug development.