DOCK2-deficiency causes defects in anti-viral T cell responses and poor control of herpes simplex virus infection
K. L. Randall, I. E. A. Flesch, Y. Mei, L. A. Miosge, R. Aye, R. Aye, Z. Yu, H. Domaschenz, N. Hollett, T. Russell, T. Stefanovic, Y. C. Wong, C. C. Goodnow, E. Bertram, A. Enders, D. Tscharke
This study shows that DOCK2-deficient mice have impaired anti-viral CD8+ T cell responses and poor control of HSV-1 infection due to defects in clonal expansion and effector function.
bioRxiv · Aug 2, 2023 · PreprintImmunology