Z. Yu

Probing the eukaryotic microbes of ruminants with a deep-learning classifier and comprehensive protein databases

The paper develops GutEuk, a deep-learning classifier, and curated protein databases to improve identification and functional analysis of eukaryotic microbes in ruminant gut metagenomes.

Deterministic processes played more important roles than stochastic processes in driving community assembly of ectomycorrhizal fungal associated with Pinus tabuliformis - an endemic Pinaceae species in China

The study examines EM fungal communities associated with Pinus tabuliformis, finding deterministic processes dominate community assembly over stochastic processes.

Muscone-specific olfactory protein reveals the putative scent-marking pheromone in the Sunda pangolin (Manis javanica)

This study identifies muscone as a potential male-specific scent-marking pheromone in Sunda pangolins through functional expression of odorant-binding proteins and behavioral assays.

Structural and functional analysis of the Nipah virus polymerase complex

This study determines the cryo-EM structure of the Nipah virus polymerase complex and identifies key domains critical for replication and transcription.

A foundation model for generalizable cancer diagnosis and survival prediction from histopathological images

This paper introduces BEPH, a lightweight foundation model for cancer diagnosis and survival prediction from histopathological images, showing improved performance over existing models with limited data.

Opto-chemogenetic inhibition of L-type CaV1 channels in neurons through a membrane-assisted molecular linkage

This paper develops a method to inhibit L-type CaV1 channels in neurons using opto-chemogenetic tools, showing acute and potent inhibition through membrane-assisted molecular linkage.

Improvement in Outcomes and Prevention of Multiple Organ Dysfunction Syndrome After Cardiac Arrest and Successful Cardiopulmonary Resuscitation by Systemic Administration of Bumetanide in Male Mice

This study shows that systemic bumetanide administration after cardiac arrest and CPR improves survival, reduces brain injury, and prevents multiple organ dysfunction in male mice, with LCN2/NGAL identified as a potential biomarker for early neuroprognostication.

Detection of High-Frequency Oscillations from Intracranial EEG Data with Switching State Space Model

This paper uses a Switching State Space Model to automatically detect high-frequency oscillations in intracranial EEG data, improving accuracy compared to manual annotation.

Perfusion-Independent Tissue Hypoxia in Cardiac Hypertrophy in Mice Measured by 64Cu-CTS PET Imaging

This study shows that 64Cu-CTS PET detects hypoxia in hypertrophic mouse hearts independent of perfusion, linking it to structural changes and metabolic shifts.

Compliant DNA Origami Nanoactuators as Size-Selective Nanopores

This paper introduces a DNA origami-based nanopore that can adjust its size through molecular triggers, enabling size-selective transport of biomolecules.

MicroRNA-27a-5p downregulates the expression of proinflammatory cytokines in lipopolysaccharide-stimulated human dental pulp cells via NF-κB signaling pathway

This study shows miR-27a-5p reduces proinflammatory cytokines in LPS-stimulated hDPCs by inhibiting NF-κB signaling through targeting TAB1.

TRIP12 governs DNA Polymerase β involvement in DNA damage response and repair

This study identifies TRIP12 as a regulator of DNA polymerase β involvement in DNA damage response and repair by controlling its trafficking and chromatin loading.

Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

The paper develops methods to image glutamatergic synapses in hippocampal tissue using cryo-electron tomography, enabling high-resolution visualization of synaptic structures.

Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast

This study reveals the architecture and flexibility of native kinetochores using structural analyses of purified kinetochores from thermophilic yeast.

Factors that influence the caste ratio in a bacterial division of labour

The paper investigates how environmental and competitive factors influence mutation frequencies in Streptomyces coelicolor colonies, showing that these frequencies are dynamic and responsive to the competitive environment.

The assembly and efflux processes revealed by in situ structures of the ABC-type tripartite pump MacAB-TolC

The paper resolves the in situ structures of the MacAB-TolC efflux pump in E. coli, revealing its assembly process and substrate-driven efflux mechanism.

Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy

This paper develops a dual-targeting compound that eliminates regulatory B cells and overcomes STING resistance in pancreatic cancer, improving immunotherapy outcomes.

Genomic insights into photosymbiotic evolution in Tridacna squamosa

This study presents the first complete genome of Tridacna squamosa and integrates multi-omics data to uncover molecular mechanisms underlying photosymbiosis with dinoflagellates.

Internal Transcribed Spacers as Phylogenetic Markers Enable Species-level Metataxonomic Analysis of Ciliated Protozoa

This paper evaluates ITS1 and ITS2 as better markers than 18S rRNA for species-level ciliate classification in freshwater and rumen environments.

Identification and Structural Characterization of a mutant KRAS-G12V specific TCR restricted by HLA-A3

The paper identifies a TCR specific to KRAS-G12V neoantigen and characterizes its structural interaction with HLA-A3, revealing challenges in targeting this mutation.

Effects of fructooligosaccharides and Saccharomyces boulardii on the compositional structure and metabolism of gut microbiota in students

This study examines how fructooligosaccharides and Saccharomyces boulardii affect gut microbiota structure and metabolism in students using an in vitro model, finding that their combination has unique benefits.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Tissue-resident alveolar macrophages reduce O3-induced inflammation via MerTK mediated efferocytosis

This study shows tissue-resident alveolar macrophages reduce O3-induced inflammation by clearing apoptotic cells via MerTK-mediated efferocytosis in mice and humans.

DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8+ T cells

The paper identifies TBKBP1 as a key gene whose demethylation enhances cytotoxic activity in CMV-specific CD8+ T cells, suggesting it as a therapeutic target.

Viruses contribute to microbial diversification in the rumen ecosystem and are associated with certain animal production traits.

This study investigates the role of the rumen virome in microbial diversification and its association with animal production traits using metagenomic data and network analysis.

Structural and mechanistic insights into human choline and ethanolamine transport

This study identifies FLVCR1 and FLVCR2 as choline and ethanolamine transporters, revealing their structural dynamics and substrate selectivity mechanisms.

Influenza A virus H1N1-derived circNP37 positively regulates viral replication by sponging host miR-361-5p

This study identifies circNP37, a circRNA derived from H1N1 influenza virus, which enhances viral replication by sequestering host miR-361-5p.

Exact solution of a three-stage model of stochastic gene expression including cell-cycle dynamics

This paper derives an exact solution for a three-stage stochastic gene expression model that includes cell-cycle dynamics, showing discrepancies with the classical model that ignores cell-cycle effects.

Hemopexin Reverses Activation of Lung eIF2a and Decreases Mitochondrial Injury in Chlorine Exposed Mice

This study shows that hemopexin reduces acute lung injury and mitochondrial damage in chlorine-exposed mice by reversing eIF2α activation and mtDNA lesions.

DOCK2-deficiency causes defects in anti-viral T cell responses and poor control of herpes simplex virus infection

This study shows that DOCK2-deficient mice have impaired anti-viral CD8+ T cell responses and poor control of HSV-1 infection due to defects in clonal expansion and effector function.