Cancer BiologybioRxiv
ETS1, a target gene of the EWSR1::FLI1 fusion oncoprotein, regulates the expression of the focal adhesion protein TENSIN3
V. J. Ebegboni, T. L. Jones, T. Brownmiller…·N. Caplen
This study identifies ETS1 as a target of the EWSR1::FLI1 fusion oncoprotein in Ewing sarcoma, showing it regulates TNS3 expression, which promotes cell movement and is linked to metastasis.
DOI 10.1158/1541-7786.mcr-23-1090