Author

E. Comer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

S. L. Schreiber· 2 shared A. G. Myers· 1 shared A. K. Chatterjee· 1 shared A. Sharma· 1 shared B. Melillo· 1 shared B. P. Klaholz· 1 shared C. C. Ence· 1 shared C. Ciarlo· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

S. L. Schreiber

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Bicyclic pyrrolidine inhibitors of Toxoplasma gondii phenylalanine t-RNA synthetase with antiparasitic potency in vitro and brain exposure

C. C. Ence, T. Uddin, J. Borrel, P. Mittal, H. Xie, J. Zoller, A. Sharma, E. Comer, S. L. Schreiber, B. Melillo, L. D. Sibley, A. K. Chatterjee

This paper describes new bicyclic pyrrolidine inhibitors of Toxoplasma gondii PheRS with improved potency, selectivity, and brain exposure compared to previous azetidine-based inhibitors.

bioRxiv · Feb 28, 2024 · PreprintMicrobiology

High throughput screen identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth

J. B. Radke, K. L. Carey, S. Shaw, S. R. Metkar, C. Mulrooney, J. P. Gale, J. A. Bittker, R. Hilgraf, E. Comer, S. L. Schreiber, H. W. Virgin, J. R. Perez, L. D. D. Sibley

This study identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth through a high-throughput screen and characterizes their mechanisms of action.

bioRxiv · Jun 2, 2018Microbiology

Tetracyclines Modify Translation By Targeting Key Human rRNA Substructures.

J. D. Mortison, M. Schenone, J. A. Myers, Z. Zhang, L. Chen, C. Ciarlo, E. Comer, S. K. Natchiar, S. A. Carr, B. P. Klaholz, A. G. Myers

This study identifies tetracyclines as targeting human rRNA substructures, modifying translation and activating the ISR, which correlates with their anti-proliferative effects in cancer cells.

bioRxiv · Feb 1, 2018Cell Biology