Author

T. Uddin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. K. Chatterjee· 2 shared L. D. Sibley· 2 shared A. Sharma· 1 shared B. Melillo· 1 shared B. Wirth· 1 shared C. C. Ence· 1 shared C. D. Goodman· 1 shared C. W. McNamara· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

A. K. Chatterjee

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

High Throughput Repurposing Screen Reveals Compounds with Activity Against Toxoplasma gondii Bradyzoites

T. Uddin, J. Xia, Y. Fu, C. W. McNamara, A. K. Chatterjee, L. D. Sibley

The paper identifies 44 compounds with >50% inhibitory effects against Toxoplasma gondii bradyzoites using a high-throughput screen and characterizes one compound's activity.

bioRxiv · Jul 1, 2024Microbiology

Bicyclic pyrrolidine inhibitors of Toxoplasma gondii phenylalanine t-RNA synthetase with antiparasitic potency in vitro and brain exposure

C. C. Ence, T. Uddin, J. Borrel, P. Mittal, H. Xie, J. Zoller, A. Sharma, E. Comer, S. L. Schreiber, B. Melillo, L. D. Sibley, A. K. Chatterjee

This paper describes new bicyclic pyrrolidine inhibitors of Toxoplasma gondii PheRS with improved potency, selectivity, and brain exposure compared to previous azetidine-based inhibitors.

bioRxiv · Feb 28, 2024 · PreprintMicrobiology

CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy

M. Zaninello, T. Schlegel, H. Nolte, P. M. U. Rehman, E. Savino, E. Barth, H. Wuestenberg, T. Uddin, L. Wolff, B. Wirth, H. Lehmann, J.-M. Cioni, T. Langer, E. Rugarli

This study shows CLUH is essential for maintaining mitochondrial function and translation in motoneuronal axons, preventing peripheral neuropathy in mice.

bioRxiv · Dec 2, 2023 · PreprintCell Biology

A single point mutation in the Plasmodium falciparum ftsh1 metalloprotease confers actinonin resistance.

C. D. Goodman, T. Uddin, N. J. Spillman, G. I. McFadden

This study identifies a single point mutation in PfFtsH1 as the cause of actinonin resistance in P. falciparum, confirming PfFtsH1 as the drug's target.

eLife · Jul 17, 2020Peer-reviewedMicrobiology