Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
S. J. Won, Y. Zhang, C. J. Reinhardt, N. S. MacRae, K. E. DeMeester, E. Njomen, L. M. Hargis, J. R. Remsberg, B. Melillo, B. F. Cravatt, M. A. Erb
This study identifies covalent small molecules that bind FOXA1, altering its chromatin remodeling activity in prostate cancer cells.
bioRxiv · Mar 21, 2024Biochemistry
C. C. Ence, T. Uddin, J. Borrel, P. Mittal, H. Xie, J. Zoller, A. Sharma, E. Comer, S. L. Schreiber, B. Melillo, L. D. Sibley, A. K. Chatterjee
This paper describes new bicyclic pyrrolidine inhibitors of Toxoplasma gondii PheRS with improved potency, selectivity, and brain exposure compared to previous azetidine-based inhibitors.
bioRxiv · Feb 28, 2024 · PreprintMicrobiology
D. Ogasawara, D. Konrad, Z. Y. Tan, K. Carey, J. Luo, S. J. Won, H. Li, T. Carter, K. DeMeester, E. Njomen, S. Schreiber, R. Xavier, B. Melillo, B. Cravatt
The paper introduces photo-stereoprobes for expanding the ligandable proteome and demonstrates their use in discovering bioactive small molecules.
bioRxiv · Feb 27, 2024Biochemistry
Y. Zhang, Z. Liu, M. Hirschi, O. Brodsky, E. Johnson, S. J. Won, A. Nagata, M. D. Petroski, J. D. Majmudar, S. Niessen, T. VanArsdale, A. M. Gilbert, M. M. Hayward, A. E. Stewart, A. R. Nager, , B. F. Cravatt
The paper uses covalent probes and paralog hopping to identify ligandable pockets in proteins lacking cysteines, demonstrating a method to expand the ligandable proteome.
bioRxiv · Jan 18, 2024 · PreprintBiochemistry
S. Shaw, I. S. Cohn, R. de Paula Baptista, G. Xia, B. Melillo, F. Agyabeng-Dadzie, J. C. Kissinger, B. Striepen
This paper demonstrates genetic crosses within and between Cryptosporidium species, showing genomic recombination and its implications for parasite adaptation and host specificity.
Proceedings of the National Academy of Sciences · Dec 26, 2023Peer-reviewedMicrobiology
K. A. Scott, H. Kojima, N. Ropek, C. D. Warren, T. L. Zhang, S. J. Hogg, C. Webster, X. Zhang, J. Rahman, B. Melillo, B. F. Cravatt, J. Lyu, O. Abdel-Wahab, E. V. Vinogradova
This study develops chemical probes to target splicing factors in T cells, showing state-dependent loss of ITK via SF3B1 and demonstrating covalent ligandability of splicing regulators.
bioRxiv · Dec 18, 2023Immunology
M. Lazear, J. Remsberg, M. Jaeger, K. Rothamel, H.-l. Her, K. DeMeester, E. Njomen, S. Hogg, J. Rahman, L. Whitby, S. J. Won, M. Schafroth, D. Ogasawara, M. Yokoyama, G. Lindsey, , B. Cravatt
This study develops a proteomic strategy to identify chemical probes that perturb protein complexes in human cells by analyzing electrophilic compounds' effects on protein interactions.
bioRxiv · Dec 12, 2022Biochemistry
L. Hudson, J. W. Mason, M. V. Westphal, M. J. R. Richter, J. R. Thielman, B. K. Hua, C. J. Gerry, G. Xia, H. L. Osswald, J. M. Knapp, Z. Y. Tan, P. Kokkonda, B. I. C. Tresco, S. Liu, A. G. Reidenbach, , K. Briner
The paper describes the design, synthesis, and validation of a 3.7 million-member DNA-encoded library using diversity-oriented synthesis to enhance structural diversity for drug discovery.
bioRxiv · Oct 16, 2022Biochemistry
C. A. Jette, C. O. Barnes, S. M. Kirk, B. Melillo, A. B. Smith, P. J. Bjorkman
The paper presents cryo-EM structures of HIV-1 Env trimers bound to CD4-mimetics, showing conformational changes induced by Phe43 pocket binding.
bioRxiv · Aug 21, 2020Biochemistry