P. Kohl

Repolarisation-relaxation dyscoupling and TRPA1 activation permit systolic mechano-arrhythmogenesis

This study shows that TRPA1 activation and disrupted repolarisation-relaxation coupling during systole contribute to mechano-arrhythmogenesis in ischaemic conditions.

3D structure of fibroblasts and macrophages in the healthy and cryo-ablated heart

The paper quantifies the 3D structure and distribution of fibroblasts and macrophages in healthy and cryo-ablated mouse hearts using fluorescent labeling and imaging.

Optogenetic confirmation of transverse-tubular membrane excitability in intact cardiac myocytes

The paper demonstrates that cardiac myocyte T-tubules can generate action potentials autonomously, distinct from those in the sarcolemma, using an all-optical method.

Perivascular Excitation Tunnelling: a Novel and Preventable Cause of Cardiac Reperfusion Arrhythmias

This study identifies perivascular excitation tunnelling (PVET) as a novel mechanism causing reperfusion arrhythmias and shows that two-step reperfusion can prevent it in rabbit and pig hearts.

Structure and dynamics of human cardiac fibroblast nanotubes

This study examines the structure and dynamics of cardiac fibroblast nanotubes in human atrial tissue and cell lines, showing their role in intercellular communication and ECM interaction.

Piezo1 stretch-activated channel activity differs between bone marrow-derived and cardiac tissue-resident macrophages

This study compares stretch-activated channel activity in bone marrow-derived and cardiac tissue-resident macrophages, finding that Piezo1 activity is absent in the latter.

Age-related structural and functional changes of the intracardiac nervous system

This study examines age-related changes in cardiac Schwann cells, parasympathetic nerve fibers, and M2R expression in mice, finding reduced SC density, fewer parasympathetic fibers, and lower M2R expression in aged hearts, which correlates with increased arrhythmia risk.

TREK-1 knock-down in human atrial fibroblasts leads to a myofibroblastic phenotype: a role in phenoconversion and overview of mechano-sensitive channel mRNA expression in cardiac diseases.

Complexes of tubulin oligomers and tau form an intervening network cross-bridging microtubules into bundles

The paper identifies an intervening network of tubulin-tau complexes that cross-link microtubules into bundles, revealing a new role for tubulin in stabilizing MT fascicles and preventing tau leakage in neurodegeneration.

The cardiac TRPA1 channel drives calcium-mediated mechano-arrhythmogenesis

The paper shows TRPA1 channels drive calcium-mediated mechano-arrhythmogenesis in cardiac cells under conditions of altered repolarization-relaxation coupling.

Cell-Accurate Optical Mapping Across The Entire Developing Heart

This study maps calcium dynamics across all cells in a developing zebrafish heart to understand how structural and functional patterns emerge during organogenesis.