De novo protein design enables precise induction of functional antibodies in vivo
F. Sesterhenn, C. Yang, J. Cramer, J. Bonet, X. Wen, L. Abriata, I. Kucharska, C.-I. Chiang, Y. Wang, G. Castoro, S. Vollers, M. Galloux, R. Charles-Adrien, E. Dheilly, S. Rosset, , B. Correia
This paper introduces a de novo protein design algorithm called TopoBuilder that generates immunogens inducing precise antibody responses against respiratory syncytial virus in mice and non-human primates.
bioRxiv · Feb 14, 2020 · PreprintBioengineering