E. Oricchio

Patient-derived lymphomoids preserve the tumor architecture and allow to assess response to therapies in lymphoma

This study develops lymphomoids from patient lymphoma samples to assess therapy response, showing consistency with clinical outcomes.

De novo design of site-specific protein interactions with learned surface fingerprints

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

De novo protein design enables precise induction of functional antibodies in vivo

This paper introduces a de novo protein design algorithm called TopoBuilder that generates immunogens inducing precise antibody responses against respiratory syncytial virus in mice and non-human primates.