M. Galloux

Engineering Tumor Stroma Morphogenesis Using Dynamic Cell-Matrix Spheroid Assembly

This paper develops a 3D self-assembly system to engineer tumor stroma-like structures using decellularized ECM and cancer cells, showing effects on malignancy and metabolism.

Structure of the N-RNA/P interface reveals mode of L/P attachment to the nucleocapsid of human metapneumovirus

The paper determines the structure of the N-RNA/P triple complex in human metapneumovirus, revealing how the polymerase attaches to the RNA template and providing a basis for therapeutic design.

Structural landscape of the Respiratory Syncytial Virus nucleocapsids

This paper presents cryo-EM structures of RSV nucleocapsids, revealing their polymorphism and unique helical symmetry due to C-terminal N interactions.

CK2 signaling from TOLLIP-dependent perinuclear endosomes is an essential feature of KRAS and NRAS mutant cancers

This study identifies TOLLIP as a critical adaptor for CK2 signaling from perinuclear endosomes in KRAS and NRAS mutant cancers, showing its role in tumor proliferation and progression.

Respiratory Syncytial virus NS1 protein targets the transactivator binding domain of MED25

This paper identifies the interaction between RSV NS1 and MED25's ACID domain, showing NS1 competes with ATF6 to inhibit innate immune gene transcription.

A novel effective live-attenuated human metapneumovirus vaccine candidate produced in the serum-free suspension DuckCelt-T17 cell platform

This study evaluates the use of DuckCelt-T17 avian cells for producing a live-attenuated HMPV vaccine candidate, showing its efficiency and scalability.

Depletion of TAX1BP1 amplifies innate immune responses during respiratory syncytial virus infection

This study shows that TAX1BP1 depletion enhances innate immune responses during RSV infection, suggesting it as a potential antiviral target.

Characterization of the interaction domains between the phosphoprotein and the nucleocapsid of human Metapneumovirus

This paper identifies the specific domains of the HMPV phosphoprotein (P) and nucleocapsid (NNuc) that mediate their interaction, showing the C-terminal 6 residues of P and the N-terminal domain of N are critical.

New look at RSV infection : tissue clearing and 3D imaging of the entire mouse lung at cellular resolution.

This study uses tissue clearing and 3D imaging to visualize RSV infection in whole mouse lungs, identifying infected cell subtypes and viral inclusion bodies.

Tetramerization of Phosphoprotein is essential for Respiratory Syncytial virus budding while its N terminal region mediates direct interactions with the Matrix protein.

This paper identifies the tetrameric structure of the Phosphoprotein (P) as essential for RSV budding and shows its direct interaction with the Matrix (M) protein during assembly.

De novo protein design enables precise induction of functional antibodies in vivo

This paper introduces a de novo protein design algorithm called TopoBuilder that generates immunogens inducing precise antibody responses against respiratory syncytial virus in mice and non-human primates.

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

This study demonstrates that a computationally designed epitope-focused immunogen enhances subdominant neutralizing antibody responses against RSV.