Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment
A. Nicolas-Boluda, J. Vaquero, S. Barrin, C. Kantari-Mimoun, M. Ponzo, G. Renault, P. Deptula, K. Pogoda, R. Bucki, I. Cascone, J. Courty, L. Fouassier, F. Gazeau, E. Donnadieu
This study shows that inhibiting collagen crosslinking reduces tumor stiffness, enhances T cell migration, and improves anti-PD-1 treatment efficacy in mouse tumor models.
bioRxiv · May 19, 2020Cancer Biology