Author

E. E. Shine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. R. Healy· 2 shared J. M. Crawford· 2 shared M. Xue· 2 shared B. Kazmierczak· 1 shared C. S. Kim· 1 shared C. Shen· 1 shared J. F. Johnston· 1 shared J. R. Patel· 1 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

A. R. Healy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structure elucidation of colibactin.

M. Xue, C. S. Kim, A. R. Healy, K. W. Wernke, Z. Wang, M. C. Frischling, E. E. Shine, W. Wang, S. B. Herzon, J. M. Crawford

This study determines the structure of colibactin using genetics, isotope labeling, tandem MS, and chemical synthesis, confirming its role in DNA cross-linking and colorectal cancer.

bioRxiv · Mar 12, 2019 · PreprintMicrobiology

Modulation of Flagellar Rotation in Surface-Attached Bacteria: A Circuit for Rapid Surface-Sensing

M. Schniederberend, J. F. Johnston, E. E. Shine, C. Shen, R. Jain, T. Emonet, B. Kazmierczak

The paper investigates how Pseudomonas aeruginosa modulates flagellar rotation after surface attachment, revealing a role for FlhF and cAMP signaling in controlling motor behavior.

bioRxiv · Mar 4, 2019Microbiology

Model colibactins exhibit human cell genotoxicity in the absence of host bacteria

E. E. Shine, M. Xue, J. R. Patel, A. R. Healy, Y. V. Surovtseva, S. Herzon, J. M. Crawford

This study shows that free model colibactins induce DNA double-strand breaks in human cells without requiring host bacteria, revealing mechanisms of genotoxicity and product diversification in colibactin biosynthesis.

bioRxiv · Sep 29, 2018Cancer Biology