C. Shen

Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and 2C-mediated replication complex formation

This study shows SCD1 regulates FMDV replication by modulating lipid metabolism and 2C-mediated replication complex formation, suggesting it as a potential drug target for positive-sense RNA viruses.

Investigation of the mechanism of accelerated biodegradation of Paracoccus-KDSPL-02

This study identifies PROKKA_01468 as a photoreceptor protein in Paracoccus-KDSPL-02 that enhances penicillin G degradation under light.

NGAL deficiency elicits Hemophilia-like bleeding and clotting disorder

This study shows NGAL deficiency causes Hemophilia-like bleeding and clotting issues by enhancing coagulation and suppressing antithrombin.

The linear and non-linear effects of CYP2C19 metaboliser status on DNA methylation: a methylome-wide association study

This study investigates how CYP2C19 metaboliser status affects DNA methylation across the genome, finding 48 CpG sites associated with both linear and non-linear effects, linked to drug metabolism and inflammation.

Borg extrachromosomal elements of methane-oxidizing archaea have conserved and expressed genetic repertoires

The paper identifies conserved genetic repertoires in Borg extrachromosomal elements of methane-oxidizing archaea and shows their higher expression than host genes.

Connecting higher order interactions with ecological stability in experimental aquatic food webs

The paper examines how higher order interactions affect community stability in aquatic protist communities by analyzing persistence and interaction strength across different community compositions.

Functional divergences of natural variations of TaNAM-A1 controlling leaf senescence initiation during wheat grain filling

This study identifies TaNAM-A1 as a key gene regulating leaf senescence and grain yield in wheat, showing functional differences among its haplotypes.

Structural insights into the allosteric inhibition of P2X4 receptors

This study reports cryo-EM structures of zebrafish P2X4 receptors bound to antagonists, revealing ligand-dependent structural changes that explain subtype-specific allosteric inhibition.

Absolute scattering length density profile of liposome bilayers obtained by SAXS combined with GIXOS - a tool to determine model biomembrane structure

This paper introduces an experimental method to determine the absolute scattering length density profile and area per lipid of liposomal bilayers using SAXS combined with GIXOS data.

SAI: Fast and automated quantification of stomatal parameters on microscope images

SAI automates stomatal parameter quantification on microscope images, achieving results consistent with human experts and improving efficiency in plant physiology research.

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

This study identifies ACE2 as the receptor for NeoCoV and PDF-2180-CoV, two close MERS-CoV relatives in bats, showing they can use bat ACE2 and, with mutation, human ACE2.

Robust and Efficient Assessment of Potency (REAP): A Quantitative Tool for Dose-response Curve Estimation

The paper introduces a robust beta regression method for dose-response curve estimation and develops a web tool for its implementation.

Full-length NLRP3 forms oligomeric cages to mediate NLRP3 sensing and activation

This study identifies full-length NLRP3 as a membrane-localized oligomeric cage that senses stimuli and activates the inflammasome, distinct from other monomeric inflammasome sensors.

Pre-existing chromatin accessibility and gene expression differences among naïve CD4+ T cells influence effector potential

The paper shows pre-existing transcriptional and chromatin differences in naive CD4+ T cells influence their effector lineage potential.

Screening of HLA-A restricted T cell epitopes of SARS-CoV-2 and induction of CD8+ T cell responses in HLA-A transgenic mice

This study identifies and validates SARS-CoV-2 CD8+ T cell epitopes, demonstrates their cross-presentation, and shows the efficacy of peptide vaccines in transgenic mice.

Molecular Response to PARP1 Inhibition in Ovarian Cancer Cells as Determined by Mass Spectrometry Based Proteomics

This study uses proteomics to analyze how ovarian cancer cells respond to PARP1 inhibition, identifying adaptive resistance mechanisms and potential therapeutic targets.

STAT3 inhibits Myocardin induced cardiac hypertrophy

The paper identifies STAT3 as an inhibitor of Myocardin-mediated cardiac hypertrophy by directly binding to Myocardin and suppressing its transcriptional activity.

Co-infection of influenza A virus enhances SARS-CoV-2 infectivity

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

An Experimental Validation of the Computer Fluid Dynamics of Normal Human Nasal Airflow Using a Precise 3-D Printing Model

This study validates CFD simulations of nasal airflow using a 3D-printed model, showing high agreement at lower flow rates but significant deviation at higher flow rates.

Viral Architecture of SARS-CoV-2 with Post-Fusion Spike Revealed by Cryo-EM

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

Seneca Valley virus intercellular transmission mediated by exosomes

This study shows that exosomes from SVV-infected cells can carry and transmit SVV between susceptible and non-susceptible cells, and this transmission is resistant to neutralizing antibodies.

Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross-sectional and whole genome sequencing based molecular epidemiological study

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

SIRT2-knockdown Rescues GARS-induced Charcot-Marie-Tooth Neuropathy

This study shows that reducing SIRT2 rescues GARS-induced neuropathy in a Drosophila model by restoring acetylated tubulin levels and axonal transport.

Iron-deficiency and estrogen are associated with ischemic stroke by up-regulating transferrin to induce hypercoagulability

The paper shows that iron-deficiency and estrogen increase transferrin, leading to hypercoagulability and worsened ischemic stroke.

Modulation of Flagellar Rotation in Surface-Attached Bacteria: A Circuit for Rapid Surface-Sensing

The paper investigates how Pseudomonas aeruginosa modulates flagellar rotation after surface attachment, revealing a role for FlhF and cAMP signaling in controlling motor behavior.