M. Xue

EMMPRIN confers metabolic advantage for monocytes and macrophages to promote disease in a model of multiple sclerosis

This study shows that EMMPRIN promotes pro-inflammatory metabolism in monocytes/macrophages, worsening multiple sclerosis, and its deletion reduces disease severity.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

NGAL deficiency elicits Hemophilia-like bleeding and clotting disorder

This study shows NGAL deficiency causes Hemophilia-like bleeding and clotting issues by enhancing coagulation and suppressing antithrombin.

A maize lipid droplet-associated protein is modulated by a virus to promote viral multiplication and infection

This study shows that rice black streaked dwarf virus recruits a maize lipid droplet-associated protein to regulate fatty acid metabolism, promoting viral multiplication and infection.

An e-cigarette aerosol generation, animal exposure and toxicants quantification system to characterize in vivo nicotine kinetics in arterial and venous blood

This paper describes a system for generating and assessing e-cigarette aerosol exposure in animals, showing higher nicotine concentrations in arterial blood compared to venous blood.

An engineered xCas12i with high activity, high specificity and broad PAM range

This paper identifies and engineers a high-fidelity Cas12i variant with broad PAM recognition and minimal off-target activity for improved genome editing.

Kalium rhodopsins: Natural light-gated potassium channels

The paper identifies KCRs, light-gated potassium channels from a fungus-like protist, which are highly selective and fast-acting, showing potential for optogenetic control of potassium gradients in neurological and cardiac diseases.

Genome-wide screen of genomic imprinting in endosperm and population-level analysis reveal allelic variation for imprinting in flax

The paper identifies imprinted genes in flax endosperm and shows their role in intraspecific variation and domestication.

PacC-dependent adaptation and modulation of host cellular pH controls hemibiotrophic invasive growth and disease development by the rice blast fungus

This study identifies the PacC-dependent pH signaling pathway in the rice blast fungus Magnaporthe oryzae, showing it regulates host pH changes and the switch between biotrophic and necrotrophic growth, essential for disease development.

Resolving an underrepresented circulating tumor cell population in lung cancer enabled by Hexokinase 2 analysis

This study identifies HK2 as a marker for detecting underrepresented CTCs in NSCLC, revealing a distinct subpopulation with unique characteristics.

Vulnerabilities of the SARS-CoV-2 virus to proteotoxicity -- opportunity for repurposed chemotherapy of COVID-19 infection

This paper identifies SARS-CoV-2 vulnerability to methylglyoxal and suggests repurposing doxorubicin and paclitaxel for COVID-19 treatment based on their ability to increase cellular methylglyoxal levels.

Depurination of colibactin-derived interstrand cross-links.

This study shows colibactin-derived interstrand cross-links (ICLs) can evolve into DNA double-strand breaks (DSBs) through depurination and phosphate elimination, leading to nicked single-strand breaks and DSBs.

Trajectories from Snapshots: Integrated proteomic and metabolic single-cell assays reveal multiple independent adaptive responses to drug tolerance in a BRAF-mutant melanoma cell line

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

Iron-deficiency and estrogen are associated with ischemic stroke by up-regulating transferrin to induce hypercoagulability

The paper shows that iron-deficiency and estrogen increase transferrin, leading to hypercoagulability and worsened ischemic stroke.

Structure elucidation of colibactin.

This study determines the structure of colibactin using genetics, isotope labeling, tandem MS, and chemical synthesis, confirming its role in DNA cross-linking and colorectal cancer.

Transcriptome analysis of fasting caecotrophy on hepatic lipid metabolism in New Zealand rabbits

This study investigates the effects of fasting caecotrophy on growth performance and lipid metabolism in rabbits using RNA-Seq, finding reduced body weight, lipid droplet accumulation, and altered gene expression related to lipid metabolism.

Model colibactins exhibit human cell genotoxicity in the absence of host bacteria

This study shows that free model colibactins induce DNA double-strand breaks in human cells without requiring host bacteria, revealing mechanisms of genotoxicity and product diversification in colibactin biosynthesis.