J. M. Crawford

This study shows IL-10 limits inflammation by restricting sphingolipid metabolism through fatty acid desaturation, with metabolic correction reducing inflammation in IL-10-deficient macrophages.

The paper identifies a novel family of bacterial piperidine alkaloids produced by Pseudomonas koreensis that mediate inter-bacterial competition in the rhizosphere, showing convergent evolution with plant alkaloids.

The paper introduces THOR, a model rhizosphere microbiome composed of three dominant taxa, to study community behavior through genetic dissection and emergent properties.

This study shows that free model colibactins induce DNA double-strand breaks in human cells without requiring host bacteria, revealing mechanisms of genotoxicity and product diversification in colibactin biosynthesis.