Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells
E. Elder, A. Lemieux, L.-M. Legault, M. Caron, V. Bertrand-Lehouillier, T. Dupas, N. J.-M. Raynal, G. Bourque, D. Sinnett, N. Gevry, S. McGraw
This paper investigates whether rescuing DNMT1 activity can reverse its loss in mouse embryonic stem cells, finding only partial reversal with lasting effects on epigenetic landscapes and cellular function.
bioRxiv · May 7, 2024Cell Biology