KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation
L. Ran, T. Ye, E. Erbs, S. Ehl, N. Spassky, I. Sumara, Z. Zhang, R. Ricci
The paper identifies KCNN4 as a mediator linking PIEZO mechanotransduction to NLRP3 inflammasome activation, showing its role in CAPS-related auto-inflammation.
bioRxiv · Mar 8, 2023Immunology