Author

E. Fink

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:diffusion model· 1 Approach:experimental assay· 1 Assay:protein structure· 1 Organism:virus· 1

Frequent Co-Authors

A. Gastia-Sastre· 1 shared A. Li· 1 shared A. Rodriguez-Hernandez· 1 shared A. Sheen· 1 shared B. K. Shoichet· 1 shared D. G. Fujimori· 1 shared F. J. Zapatero-Belinchon· 1 shared F. Li· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiophysics

A. Gastia-Sastre

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Tumor-localized interleukin-2 and interleukin-12 combine with radiation therapy to safely potentiate regression of advanced malignant melanoma in pet dogs

J. A. Stinson, M. M. P. Barbosa, A. Sheen, N. Momin, E. Fink, J. Hampel, K. Selting, R. Kamerer, K. L. Bailey, K. D. Wittrup, T. M. Fan

This study evaluates collagen-binding IL-2 and IL-12 in pet dogs with melanoma, showing local and regional therapeutic responses that suggest potential human clinical benefit.

bioRxiv · Feb 12, 2024Cancer Biology

Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

I. Singh, F. Li, E. Fink, I. Chau, A. Li, A. Rodriguez-Hernandez, I. Glenn, F. J. Zapatero-Belinchon, M. Rodriguez, K. Devkota, Z. Deng, K. White, X. Wan, N. A. Tolmachova, Y. S. Moroz, , B. K. Shoichet

The paper identifies multiple inhibitors of SARS-CoV-2 Nsp14 N7-methyltransferase using docking strategies, with some showing sub-10 M potency and selectivity.

bioRxiv · Jan 12, 2023 · PreprintBiophysics