Author

K. L. Bailey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. Mehedi· 2 shared S. N. Talukdar· 2 shared T. M. Fan· 2 shared A. B. Malik· 1 shared A. F. Gugliuzza· 1 shared A. Sheen· 1 shared B. A. DeMontigny· 1 shared B. D. Kumar· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

M. Mehedi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tumor-localized interleukin-2 and interleukin-12 combine with radiation therapy to safely potentiate regression of advanced malignant melanoma in pet dogs

J. A. Stinson, M. M. P. Barbosa, A. Sheen, N. Momin, E. Fink, J. Hampel, K. Selting, R. Kamerer, K. L. Bailey, K. D. Wittrup, T. M. Fan

This study evaluates collagen-binding IL-2 and IL-12 in pet dogs with melanoma, showing local and regional therapeutic responses that suggest potential human clinical benefit.

bioRxiv · Feb 12, 2024Cancer Biology

mTOR signaling regulates aberrant epithelial cell proliferative and migratory behaviors characteristic of airway mucous metaplasia in asthma

K. Kudrna, E. B. Staab, E. Eilers, P. Thomes, S. Maurya, S. L. Brody, T. A. Wyatt, K. L. Bailey, J. D. Dickinson

This study shows mTOR signaling drives aberrant epithelial behaviors in asthma, including proliferation and migration, and its inhibition reduces mucous metaplasia features.

bioRxiv · Feb 12, 2024 · PreprintCell Biology

RSV-induced Expanded Ciliated Cells Contribute to Bronchial Wall Thickening

S. N. Talukdar, J. Osan, K. Ryan, B. Grove, D. Perley, B. D. Kumar, S. Yang, S. Dallman, L. Hollingsworth, K. L. Bailey, M. Mehedi

This study identifies RSV-induced actin cytoskeleton expansion in ciliated cells as a novel mechanism contributing to bronchial wall thickening in adults.

bioRxiv · Oct 31, 2022Microbiology

Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants

L. Zhang, S. Dutta, S. Xiong, M. Chan, K. K. Chan, T. M. Fan, K. L. Bailey, M. Lindeblad, L. M. Cooper, L. Rong, A. F. Gugliuzza, D. Shukla, E. Procko, J. Rehman, A. B. Malik

This study shows an engineered ACE2 peptide effectively mitigates ARDS and death in mice infected with multiple SARS-CoV-2 variants.

bioRxiv · Dec 21, 2021Pharmacology & Toxicology

Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in COPD

M. Mehedi, J. K. Osan, S. N. Talukdar, F. Feldmann, B. A. DeMontigny, K. Jerome, K. L. Bailey, H. Feldmann

This study shows that goblet cells in COPD patients are more susceptible to SARS-CoV-2 infection due to higher ACE2 and TMPRSS2 expression, leading to increased viral replication.

bioRxiv · Nov 11, 2020 · PreprintMicrobiology