Author

E. Forgacs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:microscopy & imaging analysis· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. Snoberger· 1 shared B. Barua· 1 shared B. Virok· 1 shared C. Risi· 1 shared C. Scarff· 1 shared D. A. Winkelmann· 1 shared D. P. Klebl· 1 shared D. Winkelmann· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. Snoberger

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2 papers

Recent·Most cited

Swinging lever mechanism of myosin directly demonstrated by time-resolved cryoEM

D. P. Klebl, S. N. McMillan, C. Risi, E. Forgacs, B. Virok, J. Atherton, M. Stofella, D. Winkelmann, F. Sobott, V. Galkin, P. J. Knight, S. P. Muench, C. Scarff, H. D. White

This paper uses time-resolved cryoEM to directly observe the swinging lever mechanism of myosin-5, showing its structural changes during ATP hydrolysis and force generation.

bioRxiv · Jan 5, 2024 · PreprintBiochemistry

Human hypertrophic cardiomyopathy mutation R712L suppresses the working stroke of cardiac myosin and can be rescued by omecamtiv mecarbil

A. Snoberger, B. Barua, J. L. Atherton, H. Shuman, E. Forgacs, Y. E. Goldman, D. A. Winkelmann, E. M. Ostap

This study shows that the HCM mutation R712L in β-cardiac myosin reduces the working stroke, which is reversed by the drug omecamtiv mecarbil.

bioRxiv · Oct 2, 2020Biophysics