Author

J. Atherton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Assay:structural biology· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C. A. Moores· 4 shared A. D. Cook· 2 shared M. O. Steinmetz· 2 shared A. Akhmanova· 1 shared A. M. Fry· 1 shared A. Pena· 1 shared A. Roberts· 1 shared A. Roll-Mecak· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersCell Biology

C. A. Moores

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Swinging lever mechanism of myosin directly demonstrated by time-resolved cryoEM

D. P. Klebl, S. N. McMillan, C. Risi, E. Forgacs, B. Virok, J. Atherton, M. Stofella, D. Winkelmann, F. Sobott, V. Galkin, P. J. Knight, S. P. Muench, C. Scarff, H. D. White

This paper uses time-resolved cryoEM to directly observe the swinging lever mechanism of myosin-5, showing its structural changes during ATP hydrolysis and force generation.

bioRxiv · Jan 5, 2024 · PreprintBiochemistry

Visualising the cytoskeletal machinery in neuronal growth cones using cryo-electron tomography

J. Atherton, M. Stouffer, F. Francis, C. A. Moores

The paper uses cryo-electron tomography to visualize the 3D subcellular architecture of neuronal growth cones, revealing distinct F-actin and microtubule structures and their molecular modulation.

bioRxiv · Aug 6, 2021Cell Biology

Molecular mechanism of a parasite kinesin motor and implications for its inhibition

A. D. Cook, A. Roberts, J. Atherton, R. Tewari, M. Topf, C. A. Moores

This study characterizes the molecular mechanism of Plasmodium falciparum kinesin-5 (PfK5) and identifies structural features that could enable selective inhibition of this parasite's motor.

bioRxiv · Jan 26, 2021Biophysics

The mechanism of selective kinesin inhibition by kinesin binding protein.

J. Atherton, J. J. A. Hummel, N. Olieric, J. Locke, A. Pena, S. S. Rosenfeld, M. O. Steinmetz, C. C. Hoogenraad, C. A. Moores

This study identifies how kinesin binding protein selectively inhibits specific kinesins by structurally distorting their motor domains and blocking microtubule attachment.

bioRxiv · Jul 17, 2020 · PreprintBiochemistry

Structural determinants of microtubule minus end preference in CAMSAP CKK domains

J. Atherton, Y. Luo, S. Xiang, C. Yang, K. Jiang, M. Stangier, A. Vemu, A. D. Cook, S. Wang, A. Roll-Mecak, M. O. Steinmetz, A. Akhmanova, M. Baldus, C. Moores

This study compares human and Naegleria CKK domains to show how structural differences in tubulin conformations enable microtubule minus-end recognition.

bioRxiv · Mar 27, 2019Biophysics

Mitotic phosphorylation by Nek6 and Nek7 reduces microtubule affinity of EML4 to alter spindle dynamics and promote chromosome congression

A. M. Fry, R. Adib, J. M. Montgomery, J. Atherton, L. O'Regan, M. Richards, K. R. Straatman, D. Roth, A. Straube, R. Bayliss, C. A. Moores

bioRxiv · Nov 9, 2018Cell Biology