E. Frey

Robust and resource-optimal dynamic pattern formation of Min proteins in vivo

This study investigates the robustness and dynamics of Min protein oscillations in E. coli, showing their optimal expression levels and complex patterns under varying conditions.

Relict duck-billed dinosaurs survived into the last age of the dinosaurs in subantarctic Chile

This paper describes a new subantarctic duck-billed dinosaur species from Chile that survived into the Maastrichtian, suggesting earlier arrival of its lineage in South America than hadrosaurids.

Control of protein-based pattern formation via guiding cues

This paper reviews how protein patterns in cells are guided by cell size, shape, other protein patterns, and mechanical properties, and discusses their role in information processing.

Directing Min protein patterns with advective bulk flow

The paper shows that hydrodynamic bulk flow can control the direction of Min protein pattern propagation in vitro, with downstream propagation at low MinE:MinD ratios and upstream propagation at high ratios.

ATP driven diffusiophoresis: active cargo transport without motor proteins

The paper demonstrates a non-specific physical mechanism for active cargo transport using the MinDE protein system in E. coli, sorting cargo by size through diffusiophoresis.

The Time Complexity of Self-Assembly

The paper analyzes the time complexity of non-equilibrium self-assembly processes and identifies optimal control strategies for artificial self-assembly.

Tissue flow through pores: a computational study

This study uses computer simulations to show how a bottleneck in a channel affects cell monolayer organization and motion, revealing fluid-like and solid-like behaviors.

Drag-induced directionality switching of kinesin-5 Cin8 revealed by cluster-motility analysis

This study reveals that directionality switching of kinesin-5 Cin8 motors is caused by an asymmetric response to drag forces, identified through cluster-motility analysis and biophysical modeling.

PomX, a ParA/MinD ATPase activating protein, is a triple regulator of cell division in Myxococcus xanthus

This study identifies PomX as a triple regulator of cell division in Myxococcus xanthus, showing it interacts with PomZ, self-interacts, and scaffolds the PomX/Y/Z complex to position the FtsZ-ring.

Adaptability and evolution of the cell polarization machinery in budding yeast

The paper investigates how the cell polarization machinery in budding yeast evolves and adapts by analyzing its resilience and redundancy through modeling, theory, and experiments.

Dynamics of the Bacillus subtilis Min system

This study shows that the Min system in Bacillus subtilis dynamically localizes to active division sites, forming clusters, and provides physical modeling to explain its behavior.

Bulk-surface coupling reconciles Min-protein pattern formation in vitro and in vivo

This study reconciles differences in Min-protein pattern formation between in vitro and in vivo settings by showing how bulk-surface coupling influences dynamics.

Quasi-periodic migration of single cells on short microlanes

The paper studies quasi-periodic cell migration on microlanes and shows that a Cellular Potts model can recapitulate migration statistics with minimal cytoskeleton dynamics.

Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans

This study identifies geometric cues that stabilize the long-axis polarisation of PAR protein patterns in C. elegans zygotes through a reaction-diffusion model.

Cell based strain stiffening of a non-fibrous matrix as organizing principle for morphogenesis

The paper identifies a mechanism where endothelial cells form networks by mechanically stiffening a non-fibrous matrix, independent of chemical cues, and shows how matrix topology and cell contractility influence this process.

A mechanistic view of collective filament motion in active nematic networks

The paper investigates how collective filament motion in active nematic networks arises from the balance of viscous drag and motor-induced forces, showing that the ratio of these forces determines interaction range and filament velocity polarity dependence.

Design of biochemical pattern forming systems from minimal motifs

The paper designs pattern-forming biochemical systems from minimal motifs by analyzing the MinDE system and showing that adding dimerization or membrane-binding motifs can generate pattern formation.

Stochastic Yield Catastrophes and Robustness in Self-Assembly

The paper analyzes self-assembly mechanisms to delay nucleation and finds that demographic fluctuations can lead to stochastic yield catastrophes, highlighting the importance of stochasticity in self-assembly yield.

Bridging the gap between single-cell migration and collective dynamics

The paper presents a cellular-automaton model to study how cell functions influence collective migration across different system sizes, showing it can simulate up to 10^4 cells efficiently.

Can a flux-based mechanism explain positioning of protein clusters in a three-dimensional cell geometry?

The paper models PomZ flux dynamics in 3D to show how protein clusters position at midcell in M. xanthus.