S. Jun

Robust and resource-optimal dynamic pattern formation of Min proteins in vivo

This study investigates the robustness and dynamics of Min protein oscillations in E. coli, showing their optimal expression levels and complex patterns under varying conditions.

Ischemia/Reperfusion Injury and Oxidative Stress Impair Cardiac Desmin Proteostasis

This study investigates how oxidative stress and reperfusion injury affect desmin proteostasis, identifying mechanisms to reduce toxic desmin aggregates and improve cardiac function.

CRACD suppresses neuroendocrinal plasticity of lung adenocarcinoma

This study shows CRACD suppresses neuroendocrinal plasticity in lung adenocarcinoma by restricting cell de-differentiation and stemness-related pathways.

CDH1 loss defines distinct diffuse-gastric cancer subtype with T cell exhaustion and EZH2 regulon activation

This study identifies two distinct subtypes of diffuse-type gastric cancer associated with CDH1 loss, highlighting T cell exhaustion and EZH2 regulon activation.

Tumor Niche Network-Defined Subtypes Predict Immunotherapy Response of Esophageal Squamous Cell Cancer

This study defines ESCC subtypes based on tumor microenvironment transcriptional networks and predicts immunotherapy response using single-cell transcriptomics.

Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.

Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion

This study identifies key genetic drivers of ESCC initiation and immune evasion using CRISPR/Cas9 in murine organoids and human scRNA-seq data.

PCLAF-DREAM Drives Alveolar Cell Plasticity for Lung Regeneration

This study identifies PCLAF-DREAM's role in alveolar cell plasticity during lung regeneration and shows a drug candidate can pharmacologically target this process to prevent fibrosis.

Robust control of replication initiation in the absence of DnaA-ATP {leftrightharpoons} DnaA-ADP regulatory elements in Escherichia coli

The paper investigates the role of DnaA-ATP/ADP conversion in E. coli replication initiation, finding that intrinsic ATPase activity alone can maintain robust initiation, with regulatory elements enhancing stability during multifork replication.

A Remarkable Adaptive Paradigm Of Heart Performance And Protection Emerges In Response To The Constitutive Challenge Of Marked Cardiac-Specific Overexpression Of Adenylyl Cyclase Type 8

This study shows that cardiac-specific overexpression of AC8 in mice leads to adaptive cardiac changes resembling cancer-like survival mechanisms without heart failure.

Yap/Taz-Activated Tert-Expressing Acinar Cells Are Required for Pancreatic Regeneration

This study identifies Tert+ acinar cells as critical for pancreatic regeneration, showing their activation by Yap/Taz and their role in tissue repair.

Cell-type specific requirement for pyruvate dehydrogenase in hematopoiesis and leukemia development.

The paper investigates whether metabolic requirements of leukemia cells reflect normal cell type metabolism, finding that PDH is required in T cell progenitors but not other hematopoietic cells.

Single-cell analysis of a mutant library generated using CRISPR-guided deaminase

The paper develops a CRISPR-based platform combining deaminase and scRNA-seq to introduce and assess substitution mutations, enabling high-throughput analysis of mutation-associated transcriptional effects.

Multiplex generation, tracking, and functional screening of substitution mutants using a CRISPR/retron system

This paper develops a CRISPR/retron system for high-throughput generation and tracking of substitution mutations in E. coli, enabling genome-scale screening of chemical responses and fitness changes.