Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance
Y.-S. Huoh, B. Wu, S. Park, D. Yang, K. Bansal, E. Greenwald, W. P. Wong, D. Mathis, S. Hur
This study shows that Aire's CARD-mediated multimerization forms nuclear foci and affects transcriptional activity, but also increases susceptibility to PML body interactions, which can impair its function.
bioRxiv · Feb 26, 2020Immunology