D. Mathis

Expansion of mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis

The paper examines T cell changes in mammary glands during pregnancy and lactation, finding an expansion of T effector cells and similarities to intestinal T cells.

The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis

The paper identifies a unique population of regulatory T cells in the murine meninges that maintain brain homeostasis by suppressing interferon-gamma-producing lymphocytes and preventing hippocampal damage.

An interwoven network of transcription factors, with divergent influences from FoxP3, underlies Treg diversity

The paper defines the Treg regulatory network using single-cell chromatin accessibility and machine learning, revealing FoxP3's limited role in shaping Treg diversity.

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets

The paper investigates relationships between colon T regulatory cell subsets, finding that their phenotypes are influenced by tissue-specific cues rather than their differentiation origin.

A dynamic atlas of immunocyte migration from the gut

The paper maps immunocyte migration from the gut using single-cell genomics and a photoconvertible mouse model, showing lineage-specific emigration patterns and their influence on peripheral immunity.

FoxP3 associates with enhancer-promoter loopsto regulate Treg-specific gene expression

This study identifies FoxP3's role in Treg cell identity by showing its association with enhancer-promoter loops and its correlation with heightened enhancer-promoter cross-talk.

Profound Treg perturbations correlate with COVID-19 severity

The paper identifies Treg cell perturbations in severe COVID-19 patients, showing increased FoxP3 levels and pro-inflammatory traits linked to disease severity.

Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations

The paper analyzes FOXP3 deficiencies in humans and mice using single-cell RNA-seq and flow cytometry to uncover intrinsic and extrinsic CD4+ T cell perturbations in IPEX syndrome.

Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

This study shows that Aire's CARD-mediated multimerization forms nuclear foci and affects transcriptional activity, but also increases susceptibility to PML body interactions, which can impair its function.