Structures of TRPM5 channel elucidate mechanism of activation and inhibition
W. Lu, J. Du, Z. Ruan, E. Haley, I. Orozco, R. Roth, M. Sabat, R. Myers
This paper reports cryo-EM structures of TRPM5 channels in different states, revealing mechanisms of activation and inhibition through ligand binding sites.
bioRxiv · Mar 25, 2021Biophysics