Oncogenic Ras activation in permissive somatic cells triggers rapid onset phenotypic plasticity and elicits a tumour-promoting neutrophil response
A. M. Elliot, I. Ribeiro Bravo, J. Astorga Johansson, E. Hutton, R. Cunningham, H. Myllymaki, K. Y. Chang, J. Cholewa-Waclaw, Y. Zhao, R. Dobie, M. Beltran, A. Lewis, P. Elks, C. G. Hansen, N. Henderson, Y. Feng
This study shows that oncogenic Ras in zebrafish skin triggers phenotypic plasticity in specific keratinocytes and promotes tumour-promoting neutrophils within 24 hours.
bioRxiv · Nov 10, 2023 · PreprintCancer Biology