Author

R. Cunningham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:zebrafish· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. G. Hansen· 2 shared A. Lewis· 1 shared A. M. Elliot· 1 shared A. M. Hoy· 1 shared A. S. Mirchandani· 1 shared B. Malissen· 1 shared C. C. Bain· 1 shared C. M. Mawer· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

C. G. Hansen

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Author profile →

5 papers

Recent·Most cited

Cas9 RNP Physiochemical Analysis for Enhanced CRISPR-AuNP Assembly and Function

D. D. Lane, K. S. V. Gottimukkala, R. Cunningham, M. E. Cassidy, Y. Jwa, J. M. P. Castelli, J. E. Adair

This paper improves CRISPR-AuNP delivery by optimizing Cas9 RNP loading and nanoparticle surface chemistry, achieving higher RNP loading and uptake in HSPCs but with limited endosomal escape.

bioRxiv · Apr 2, 2024 · PreprintBioengineering

Oncogenic Ras activation in permissive somatic cells triggers rapid onset phenotypic plasticity and elicits a tumour-promoting neutrophil response

A. M. Elliot, I. Ribeiro Bravo, J. Astorga Johansson, E. Hutton, R. Cunningham, H. Myllymaki, K. Y. Chang, J. Cholewa-Waclaw, Y. Zhao, R. Dobie, M. Beltran, A. Lewis, P. Elks, C. G. Hansen, N. Henderson, Y. Feng

This study shows that oncogenic Ras in zebrafish skin triggers phenotypic plasticity in specific keratinocytes and promotes tumour-promoting neutrophils within 24 hours.

bioRxiv · Nov 10, 2023 · PreprintCancer Biology

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

J. McCowan, P. M. Kirkwood, F. Fercoq, W. T'Jonck, C. M. Mawer, R. Cunningham, A. S. Mirchandani, A. M. Hoy, G.-R. Jones, C. G. Hansen, N. Hirani, S. J. Jenkins, S. Henri, B. Malissen, S. R. Walmsley, , C. C. Bain

This study identifies EGR2 as essential for the identity and function of alveolar macrophages in health and tissue repair.

bioRxiv · May 6, 2021Immunology

Structural basis for adhesion G protein-coupled receptor Gpr126 function

K. Leon, R. Cunningham, J. Riback, E. Feldman, J. Li, T. Sosnick, M. Zhao, K. Monk, D. Arac

This study determines the structure of the zebrafish Gpr126 ECR, revealing a closed conformation stabilized by alternative splicing and a calcium-binding site, and shows how these features regulate receptor function.

bioRxiv · Oct 17, 2019Biochemistry

Can machine learning automatically detect the aligned trunk in sitting directly from raw video using a depth camera?

M. B. Sanchez, R. Cunningham, P. B. Butler, I. Loram

This paper tests if a deep convolutional neural network can automatically detect aligned trunk posture in sitting from raw HD+D video, achieving 92.7% average precision.

bioRxiv · May 17, 2019 · PreprintBioengineering