Author

E. J. Worden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:structural biology· 2 Organism:human· 1

Frequent Co-Authors

C. Wolberger· 2 shared N. Hoffmann· 2 shared B. Knutson· 1 shared C. Hicks· 1 shared K. E. Namitz· 1 shared M. L. Smith· 1 shared M. S. Cosgrove· 1 shared S. Rahman· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 23 mutual co-author links

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2 shared papersBiophysics

C. Wolberger

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintApr 4, 2022

Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome

N. Hoffmann, S. Rahman, E. J. Worden…·C. Wolberger

The paper determines structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosomes using cryo-EM and mass spectrometry-crosslinking, revealing multiple states and the role of ubiquitin in complex assembly.

DOI 10.1101/2022.04.04.486905

humanstructural biology

𝕏 PostBluesky

BiochemistrybioRxivDec 22, 2018

The mechanism of cross-talk between histone H2B ubiquitination and H3 methylation by Dot1L

E. J. Worden, N. Hoffmann, C. Hicks, C. Wolberger

This study reveals how H2B ubiquitination enables Dot1L to methylate H3K79 by inducing a conformational change in histone H3.

DOI 10.1016/j.cell.2019.02.002

structural biologyexperimental assay

𝕏 PostBluesky